Factor VIII: Difference between revisions

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== Disease ==
== Disease ==


Defects in the protein result in hemophilia A.
Defects in the protein result in [[Hemophilia|hemophilia]] A.


== Relevance ==
== Relevance ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}


[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]] – hFVIII – human<br />
[[2r7e]], [[3cdz]], [[3j2q]], [[4bdv]], [[6mf2]] – hFVIII 19-760+1582-2351 – human<br />
[[3hnb]], [[3hny]], [[3hob]] – hFVIII light chain C2 domain<br />
[[6mf0]] – h/pFVIII<br />
[[3hnb]], [[3hny]], [[3hob]], [[4pt6]] – hFVIII light chain C2 domain 2189-2347<br />
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
[[1d7p]] - hFVIII light chain C2 domain (mutant)<br />
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
[[1cfg]], [[1fac]] - hFVIII light chain C2 domain membrane-binding peptide - NMR<br />
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
[[7k66]], [[7kbt]] – h/pFVIII + antibody<br />
[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />
[[4xzu]] - hFVIII light chain C2 domain + monoclonal Fab <br />
[[4pt6]] - hFVIII discoidin domain <br />
[[1iqd]] - hFVIII light chain C2 domain (mutant) + monoclonal Fab<br />
[[3j2s]] - hFVIII light chain 1710-2356<br />
[[5k8d]] - hFVIII heavy chain + light chain residues 104-329<br />
[[7kwo]] – hFVIII + VWF-XTEN<br />
[[4mo3]] - pFVIII light chain C2 domain – pig<br />
[[7s0p]] - pFVIII light chain C2 domain + phosphatidylserine<br />
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
[[4ki5]] - mFVIII light chain C2 domain + monoclonal Fab – mouse<br />
[[3j2s]] - hFVIII light chain<br />
[[5k8d]] - hFVIII heavy chain + light chain residus 104-329<br />
[[4mo3]] - FVIII light chain C2 domain – pig<br />
== References ==
== References ==
<references/>
<references/>

Latest revision as of 08:56, 27 February 2023

Glycosylated human Factor VIII. Residues 19-760 (cyan), 1582-2351 (magenta) complex with Ca+2 (green) and Cu+2 (orange) ions (PDB code 2r7e)

Drag the structure with the mouse to rotate

3D Structures of Factor VIII

Updated on 27-February-2023

factor IXa, Factor VIII (Hebrew), 2r7e, hemophilia, 6mf2 – hFVIII 19-760+1582-2351 – human
6mf0 – h/pFVIII
3hnb, 3hny, 3hob, 4pt6 – hFVIII light chain C2 domain 2189-2347
1d7p - hFVIII light chain C2 domain (mutant)
1cfg, 1fac - hFVIII light chain C2 domain membrane-binding peptide - NMR
7k66, 7kbt – h/pFVIII + antibody
4xzu - hFVIII light chain C2 domain + monoclonal Fab
1iqd - hFVIII light chain C2 domain (mutant) + monoclonal Fab
3j2s - hFVIII light chain 1710-2356
5k8d - hFVIII heavy chain + light chain residues 104-329
7kwo – hFVIII + VWF-XTEN
4mo3 - pFVIII light chain C2 domain – pig
7s0p - pFVIII light chain C2 domain + phosphatidylserine
4ki5 - mFVIII light chain C2 domain + monoclonal Fab – mouse

References

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel