6nfa: Difference between revisions
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==Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity== | |||
<StructureSection load='6nfa' size='340' side='right'caption='[[6nfa]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6nfa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NFA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9K1:(2S)-2-{[3-(4-methylphenyl)imidazo[1,2-a]pyrazin-8-yl]amino}-3-(pyridin-3-yl)propan-1-ol'>9K1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: Elling | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nfa OCA], [https://pdbe.org/6nfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nfa RCSB], [https://www.ebi.ac.uk/pdbsum/6nfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nfa ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/VAV_HUMAN VAV_HUMAN] Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Elling RA]] | |||
[[Category: Knapp MS]] | |||
[[Category: Ornelas E]] | |||
Latest revision as of 06:52, 11 October 2023
Vav1 inhibited by an allosteric inhibitor: Vav1 inhibitors block GEF activity
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