6otb: Difference between revisions
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==NMR structure of alpha conotoxin SII== | |||
<StructureSection load='6otb' size='340' side='right'caption='[[6otb]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6otb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_striatus Conus striatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6OTB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6OTB FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6otb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6otb OCA], [https://pdbe.org/6otb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6otb RCSB], [https://www.ebi.ac.uk/pdbsum/6otb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6otb ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CAS2_CONST CAS2_CONST] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (PubMed:1390774). This toxin potently inhibits the rodent muscle nAChR (IC(50)=120 nM (adult subtype, alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) and IC(50)=370 nM (fetal subtype, alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND)) and weakly inhibits neuronal nAChRs (PubMed:35357806). In contrast to alpha-conotoxins bearing 2 disulfide bonds (framework I), this conotoxin acts via a unique binding mode with the helix and the N- and C-termini buried in the binding pocket of muscle nAChRs (PubMed:35357806).<ref>PMID:1390774</ref> <ref>PMID:35357806</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Conus striatus]] | |||
[[Category: Large Structures]] | |||
[[Category: Alewood PF]] | |||
[[Category: Chin YK-Y]] | |||
[[Category: Wilhelm P]] | |||
Latest revision as of 10:57, 14 June 2023
NMR structure of alpha conotoxin SII
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