6rnl: Difference between revisions
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New page: '''Unreleased structure''' The entry 6rnl is ON HOLD Authors: McQuaid, K.T., Hall, J.P., Cardin, C.J. Description: L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAG... |
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==L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT)== | |||
<StructureSection load='6rnl' size='340' side='right'caption='[[6rnl]], [[Resolution|resolution]] 1.88Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6rnl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RNL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RKL:RU(TAP)2(DPPZ)+COMPLEX'>RKL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rnl OCA], [https://pdbe.org/6rnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rnl RCSB], [https://www.ebi.ac.uk/pdbsum/6rnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rnl ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Lambda-[Ru(TAP)2(dppz)]2+ was crystallised with the G-quadruplex-forming heptamer d(TAGGGTT). Surprisingly, even though there are four unique binding sites, the complex is not in contact with any G-quartet surface. Two complexes stabilise cavities formed from terminal T.A and T.T mismatched pairs. A third shows kinking by a TAP ligand between T.T linkages, while the fourth shows sandwiching of a dppz ligand between a T.A/T.A quadruplex and a T.T mismatch, stabilised by an additional T.A base pair stacking interaction on a TAP surface. Overall, the structure shows an unexpected affinity for thymine, and suggests models for G-quadruplex loop binding. | |||
Three thymine/adenine binding modes of the ruthenium complex Lambda-[Ru(TAP)(2)(dppz)](2+) to the G-quadruplex forming sequence d(TAGGGTT) shown by X-ray crystallography.,McQuaid K, Hall JP, Baumgaertner L, Cardin DJ, Cardin CJ Chem Commun (Camb). 2019 Jul 30;55(62):9116-9119. doi: 10.1039/c9cc04316k. PMID:31298665<ref>PMID:31298665</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 6rnl" style="background-color:#fffaf0;"></div> | ||
[[Category: Cardin | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Cardin CJ]] | |||
[[Category: Hall JP]] | |||
[[Category: McQuaid KT]] | |||
Latest revision as of 18:31, 8 September 2026
L-[Ru(TAP)2(dppz)]2+ bound to the G-quadruplex forming sequence d(TAGGGTT)
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