6plf: Difference between revisions
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==Crystal structure of human PHGDH complexed with Compound 1== | |||
<StructureSection load='6plf' size='340' side='right'caption='[[6plf]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6plf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PLF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ONV:4-{(1S)-1-[(5-chloro-6-{[(5S)-2-oxo-1,3-oxazolidin-5-yl]methoxy}-1H-indole-2-carbonyl)amino]-2-hydroxyethyl}benzoic+acid'>ONV</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6plf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plf OCA], [https://pdbe.org/6plf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6plf RCSB], [https://www.ebi.ac.uk/pdbsum/6plf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6plf ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[https://omim.org/entry/601815 601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN] | |||
==See Also== | |||
*[[Phosphoglycerate dehydrogenase|Phosphoglycerate dehydrogenase]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Lakshminarasimhan D]] | |||
[[Category: Olland A]] | |||
[[Category: Suto RK]] | |||
[[Category: White A]] | |||
Latest revision as of 14:55, 13 March 2024
Crystal structure of human PHGDH complexed with Compound 1
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