Matriptase: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>.  The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres.
ST14 active site has the conformation of a typical serine protease like trypsin or chymotrypsin with the <scene name='59/595760/Cv/5'>Ser-His-Asp catalytic triad</scene> and <scene name='59/595760/Cv/6'>Gly-Ser oxyanion hole</scene>.  The <scene name='59/595760/Cv/7'>inhibitor benzamidine blocks the catalytic triad</scene><ref>PMID:11696548</ref>. Water molecules shown as red spheres.
</StructureSection>


== 3D Structures of matriptase ==
== 3D Structures of matriptase ==
[[Matriptase 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*'''matriptase'''
 
**[[4is5]] – hST14 catalytic domain - human<br />
 
*Matriptase complex with small molecule inhibitor
 
**[[1eax]] – hST14 catalytic domain + benzamidine <br />
**[[3p8g]] – hST14 residues 182-422 (mutant) + benzamidine <br />
**[[2gv6]] – hST14 catalytic domain + benzamidine derivative<br />
**[[4o97]], [[4o9v]] – hST14 catalytic domain + benzamidine derivative + tetrapeptide<br />
**[[3ncl]] – hST14 catalytic domain (mutant) + benzamidine derivative<br />
**[[2gv7]], [[4jz1]], [[4jzi]], [[4jyt]] – hST14 catalytic domain + inhibitor<br />
 
*Matriptase complex with polypeptide inhibitor
 
**[[1eaw]] – hST14 catalytic domain + BPTI<br />
**[[3bn9]] – hST14 catalytic domain + antibody<br />
**[[3nps]], [[3so3]] – hST14 catalytic domain (mutant) + antibody<br />
**[[3p8f]] – hST14 residues 182-422 (mutant) + trypsin inhibitor peptide <br />
**[[4isl]], [[4isn]], [[4iso]] – hST14 catalytic domain (mutant) + Kunitz-type protease inhibitor <br />
}}


== References ==
== References ==

Latest revision as of 10:42, 28 October 2019

Structure of human matriptase catalytic domain complex with benzamidine and sulfate (PDB code 1eax).

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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