6pww: Difference between revisions
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==Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome== | |||
<SX load='6pww' size='340' side='right' viewer='molstar' caption='[[6pww]], [[Resolution|resolution]] 4.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6pww]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PWW FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pww OCA], [https://pdbe.org/6pww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pww RCSB], [https://www.ebi.ac.uk/pdbsum/6pww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pww ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RBBP5_HUMAN RBBP5_HUMAN] In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.<ref>PMID:19556245</ref> | |||
==See Also== | |||
*[[Histone 3D structures|Histone 3D structures]] | |||
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] | |||
[[Category: | *[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | ||
*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</SX> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Xenopus laevis]] | |||
[[Category: Ayoub A]] | |||
[[Category: Cho U]] | |||
[[Category: Cianfrocco MA]] | |||
[[Category: Dou Y]] | |||
[[Category: Lee YT]] | |||
[[Category: Park SH]] | |||
[[Category: Su M]] | |||
[[Category: Xu J]] | |||
[[Category: Zhang B]] | |||
[[Category: Zhang W]] | |||
[[Category: Zhang Y]] | |||
Latest revision as of 09:27, 20 March 2024
Cryo-EM structure of MLL1 in complex with RbBP5 and WDR5 bound to the nucleosome
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