6jt3: Difference between revisions
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<StructureSection load='6jt3' size='340' side='right'caption='[[6jt3]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='6jt3' size='340' side='right'caption='[[6jt3]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6jt3]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JT3 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[6jt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6JT3 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C83:N-[3-[( | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C83:~{N}-[3-[(4~{R},5~{R},6~{R})-2-azanyl-5-fluoranyl-4,6-dimethyl-5,6-dihydro-1,3-thiazin-4-yl]-4-fluoranyl-phenyl]-5-(fluoranylmethoxy)pyrazine-2-carboxamide'>C83</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6jt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jt3 OCA], [https://pdbe.org/6jt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6jt3 RCSB], [https://www.ebi.ac.uk/pdbsum/6jt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6jt3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6jt3" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6jt3" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Beta secretase 3D structures|Beta secretase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ando S]] | |||
[[Category: Ando | [[Category: Asada N]] | ||
[[Category: Asada | [[Category: Austin N]] | ||
[[Category: Austin | [[Category: Bergh AVD]] | ||
[[Category: Bergh | [[Category: Borghys H]] | ||
[[Category: Borghys | [[Category: Dhuyvetter D]] | ||
[[Category: Dhuyvetter | [[Category: Fuchino K]] | ||
[[Category: Fuchino | [[Category: Fujimoto K]] | ||
[[Category: Fujimoto | [[Category: Fukushima T]] | ||
[[Category: Fukushima | [[Category: Gijsen HJM]] | ||
[[Category: Gijsen | [[Category: Iso Y]] | ||
[[Category: Iso | [[Category: Ito H]] | ||
[[Category: Ito | [[Category: Kanegawa N]] | ||
[[Category: Kanegawa | [[Category: Kido Y]] | ||
[[Category: Kido | [[Category: Komano K]] | ||
[[Category: Komano | [[Category: Kusakabe KI]] | ||
[[Category: Kusakabe | [[Category: Matsuoka E]] | ||
[[Category: Matsuoka | [[Category: Nakahara K]] | ||
[[Category: Nakahara | [[Category: Sakaguchi G]] | ||
[[Category: Sakaguchi | [[Category: Suzuki S]] | ||
[[Category: Suzuki | [[Category: Tadano G]] | ||
[[Category: Tadano | [[Category: Teisman A]] | ||
[[Category: Teisman | [[Category: Urmaliya V]] | ||
[[Category: Urmaliya | [[Category: Yamamoto T]] | ||
[[Category: Yamamoto | [[Category: Yamano Y]] | ||
[[Category: Yamano | [[Category: Yoshida S]] | ||
[[Category: Yoshida | |||
Latest revision as of 12:47, 6 November 2024
Crystal Structure of BACE1 in complex with N-{3-[(4R,5R,6R)-2-amino-5-fluoro-4,6-dimethyl-5,6-dihydro-4H-1,3-thiazin-4-yl]-4-fluorophenyl}-5-(fluoromethoxy)pyrazine-2-carboxamide
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