Nonstructural protein: Difference between revisions
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<StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'> | <StructureSection load='1nhu' size='350' side='right' caption='Hepatitis virus nonstructural protein complex with non-nucleoside analogue inhibitor (PDB entry [[1nhu]])' scene='46/461364/Cv/1'> | ||
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[[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see<br /> | [[Nonstructural protein]] (NS) is a protein encoded by a virus which is not part of the viral particle<ref>PMID:23405236</ref>. Pestivirus encode a NS at the N-terminal of their polyproteins (Npro). For homology model and multiple sequence alignment see<br /> | ||
*[[User:Michael Strong/H1N1/NS]]<br /> | *[[User:Michael Strong/H1N1/NS]]<br /> | ||
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*[[User:Michael Strong/H1N1/NS2/MSA]]<br /> | *[[User:Michael Strong/H1N1/NS2/MSA]]<br /> | ||
*[[Student Project 4 for UMass Chemistry 423 Spring 2015]]. | *[[Student Project 4 for UMass Chemistry 423 Spring 2015]]. | ||
For NS1 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP1]].<br /> | |||
For NS2 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP2]].<br /> | |||
For NS3 of SARS-CoV-2 see [[SARS-CoV-2 enzyme Papain-like]].<br /> | |||
For NS4 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP4]].<br /> | |||
For NS6 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP6]].<br /> | |||
For NS7 or '''replicase polyprotein 1ab light chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP7]].<br /> | |||
For NS8 or '''replicase polyprotein 1ab heavy chain''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP8]].<br /> | |||
For NS9 of SARS-CoV-2 see [[SARS-CoV-2 protein NSP9]].<br /> | |||
For NS10 or '''replicase polyprotein 1ab''' of SARS-CoV-2 see [[SARS-CoV-2 protein NSP10]].<br /> | |||
For NS12 of SARS-CoV-2 see also [[Vitamin B12 may inhibit RNA‐dependent‐RNA polymerase activity of nsp12 from the SARS‐CoV‐2 vi]].<br /> | |||
For NS12+NS8+NS7 or RNA-dependent RNA polymerase of SARS-CoV-2 see [[SARS-CoV-2 enzyme RdRp]].<br /> | |||
SARS-CoV-2 NS12+NS8+NS7+NS13+RNA is called '''replication-transcription complex'''.<br /> | |||
For NS16+NS10 of SARS-CoV-2 see [[SARS-CoV-2 enzyme 2'-O-MT]].<br /> | |||
For NS13 of SARS-CoV-2 see [[Unwinding the helicase NSP13]].<br /> | |||
== Relevance == | |||
The drug Victrelis (generic name boceprevir) binds to NS3 of the hepatitis C virus and is used for treatment of the disease. See [[Bailey Dove/Victrelis]]. | |||
== Structural highlights == | == Structural highlights == | ||
