6lx3: Difference between revisions
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New page: '''Unreleased structure''' The entry 6lx3 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Cryo-EM structure of human secretory immunoglobulin A== | |||
<StructureSection load='6lx3' size='340' side='right'caption='[[6lx3]], [[Resolution|resolution]] 3.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LX3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.15Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lx3 OCA], [https://pdbe.org/6lx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lx3 RCSB], [https://www.ebi.ac.uk/pdbsum/6lx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lx3 ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Secretory Immunoglobulin A (SIgA) is the most abundant antibody at the mucosal surface. It possesses two additional subunits besides IgA: the joining chain (J-chain) and secretory component (SC). SC is the ectodomain of the polymeric immunoglobulin receptor (pIgR), which functions to transport IgA to the mucosa. How the J-chain and pIgR/SC facilitate the assembly and secretion of SIgA remains incompletely understood. Furthermore, during the infection of Streptococcus pneumoniae, the pneumococcal adhesin SpsA hijacks pIgR/SC and SIgA to gain entry to human cells and evade host defense. How SpsA targets pIgR/SC and SIgA also remains elusive. Here we report a cryo-electron microscopy structure of the Fc region of IgA1 (Fcalpha) in complex with the J-chain and SC (Fcalpha-J-SC), which reveals the organization principle of SIgA. We also present a structure of Fcalpha-J-SC complexed with SpsA, which uncovers the specific interactions between SpsA and human pIgR/SC. These results advance the molecular understanding of SIgA and shed light on S. pneumoniae pathogenesis. | |||
Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin.,Wang Y, Wang G, Li Y, Zhu Q, Shen H, Gao N, Xiao J Cell Res. 2020 May 12. pii: 10.1038/s41422-020-0336-3. doi:, 10.1038/s41422-020-0336-3. PMID:32398862<ref>PMID:32398862</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 6lx3" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Li Y]] | |||
[[Category: Wang G]] | |||
[[Category: Wang Y]] | |||
[[Category: Xiao J]] | |||
Latest revision as of 05:49, 3 July 2025
Cryo-EM structure of human secretory immunoglobulin A
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