Elevated B2M levels are found in patients of liver chirossis<ref>PMID:3884477</ref> and hepatitis<ref>PMID:29221492</ref>. Dialysis-associated amyloidosis is a serious complication in chronic dialysis patients. It is caused by B2M fibrils amyloid deposits<ref>PMID:10737162</ref>.
Elevated B2M levels are found in patients of liver cirrhosis<ref>PMID:3884477</ref> and hepatitis<ref>PMID:29221492</ref>. Dialysis-associated amyloidosis is a serious complication in chronic dialysis patients. It is caused by B2M fibrils amyloid deposits<ref>PMID:10737162</ref>.
== Relevance ==
== Relevance ==
Latest revision as of 08:10, 26 February 2020
Humanβ-2 microglobulin (green) complex with MHC I (magenta) and HCMV PP65 nonapeptide (cyan), 3mrb
Elevated B2M levels are found in patients of liver cirrhosis[2] and hepatitis[3]. Dialysis-associated amyloidosis is a serious complication in chronic dialysis patients. It is caused by B2M fibrils amyloid deposits[4].
Relevance
B2M is used as a marker for certain types of blood cell cancer. It can indicate the spread and severity of myeloma.
↑Liu C, Sawaya MR, Eisenberg D. beta-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages. Nat Struct Mol Biol. 2011 Jan;18(1):49-55. Epub 2010 Dec 5. PMID:21131979 doi:10.1038/nsmb.1948
↑Nyberg A, Loof L, Hallgren R. Serum beta 2-microglobulin levels in primary biliary cirrhosis. Hepatology. 1985 Mar-Apr;5(2):282-5. doi: 10.1002/hep.1840050222. PMID:3884477 doi:https://dx.doi.org/10.1002/hep.1840050222
↑Okoror LE, Ajayi AO, Ijalana OB. Elevated serum beta2-microglobulin in individuals coinfected with hepatitis B and hepatitis D virus in a rural settings in Southwest Nigeria. BMC Res Notes. 2017 Dec 8;10(1):719. doi: 10.1186/s13104-017-3015-9. PMID:29221492 doi:https://dx.doi.org/10.1186/s13104-017-3015-9
