Furin: Difference between revisions
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Michal Harel (talk | contribs) New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function '''Furin''' or '''proprotein convertase furin''' or '''dibasic-processi... |
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<StructureSection load='6eqv' size='340' side='right' caption='Human furin complex with peptide inhibitor, Ca++ (green), Na+ (purple), citrulline, phenylacetaldehyde and aminoetyl-benzenecarboximiidamide (PDB [[6eqv]])' scene=''> | |||
<StructureSection load=' | __TOC__ | ||
== Function == | |||
== Function | |||
'''Furin''' or '''proprotein convertase furin''' or '''dibasic-processing enzyme''' or '''paired basic amino acid residue-cleaving enzyme''' or '''PACE''' is a member of the proprotein convertase family and promotes the proteoplytic maturation of proproteins. Furin cleaves precursor proteins at their paired basic amino acid processing sites<ref>PMID:12360192</ref>. | '''Furin''' or '''proprotein convertase furin''' or '''dibasic-processing enzyme''' or '''paired basic amino acid residue-cleaving enzyme''' or '''PACE''' is a member of the proprotein convertase family and promotes the proteoplytic maturation of proproteins. Furin cleaves precursor proteins at their paired basic amino acid processing sites<ref>PMID:12360192</ref>. | ||
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== Relevance == | == Relevance == | ||
High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>. Furin has a role in atherosclerosis<ref>PMID:28400053</ref>. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>. | High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and <ref>PMID:28369813</ref>. Furin has a role in atherosclerosis<ref>PMID:28400053</ref>. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals<ref>PMID:32057769</ref>. See [[SARS-CoV-2 protein S priming by furin]], an animation. | ||
== Structural highlights == | <!--== Structural highlights == --> | ||
</StructureSection> | </StructureSection> | ||
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[[5jxg]], [[5jxi]] - hFur - human<br /> | [[5jxg]], [[5jxi]] - hFur - human<br /> | ||
[[ | [[4z2a]] - hFur (mutant)<br /> | ||
[[5mim]] - hFur + inhibitor<br /> | [[4omc]], [[4omd]], [[4ryd]], [[5jxh]], [[5jxj]], [[6eqv]], [[6eqw]], [[6eqx]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]], [[8b4x]], [[8oyh]] - hFur + peptide inhibitor<br /> | ||
[[5mim]], [[6yd2]], [[6yd3]], [[6yd4]], [[6yd7]], [[7lcu]], [[7o1u]], [[7o1w]], [[7o1y]], [[7o20]], [[7o22]], [[7qxy]], [[7qxz]], [[7qy0]], [[7qy2]], [[8b4v]], [[8b4w]] - hFur + inhibitor<br /> | |||
[[5jmo]] - hFur + antibody<br /> | |||
[[1p8j]] - mFur + peptide inhibitor - mouse<br /> | [[1p8j]] - mFur + peptide inhibitor - mouse<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:06, 7 July 2025
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3D structures of furin
Updated on 07-July-2025
SARS-CoV-2 protein S priming by furin, 5jxi - hFur - human
4z2a - hFur (mutant)
4omc, 4omd, 4ryd, 5jxh, 5jxj, 6eqv, 6eqw, 6eqx, 6hlb, 6hld, 6hle, 6hza, 6hzb, 6hzc, 6hzd, 8b4x, 8oyh - hFur + peptide inhibitor
5mim, 6yd2, 6yd3, 6yd4, 6yd7, 7lcu, 7o1u, 7o1w, 7o1y, 7o20, 7o22, 7qxy, 7qxz, 7qy0, 7qy2, 8b4v, 8b4w - hFur + inhibitor
5jmo - hFur + antibody
1p8j - mFur + peptide inhibitor - mouse
