6wsa: Difference between revisions

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'''Unreleased structure'''


The entry 6wsa is ON HOLD
==Crystal structure of a betaine aldehyde dehydrogenase from Burkholderia pseudomallei without cofactor==
<StructureSection load='6wsa' size='340' side='right'caption='[[6wsa]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[6wsa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Burkholderia_pseudomallei_1710b Burkholderia pseudomallei 1710b]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WSA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WSA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SIN:SUCCINIC+ACID'>SIN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wsa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wsa OCA], [https://pdbe.org/6wsa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wsa RCSB], [https://www.ebi.ac.uk/pdbsum/6wsa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wsa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BETB_BURP1 BETB_BURP1] Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.[HAMAP-Rule:MF_00804]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei.


Authors: Seattle Structural Genomics Center for Infectious Disease
Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.,Beard DK, Subramanian S, Abendroth J, Dranow DM, Edwards TE, Myler PJ, Asojo OA Acta Crystallogr F Struct Biol Commun. 2022 Feb 1;78(Pt 2):45-51. doi:, 10.1107/S2053230X21013455. Epub 2022 Jan 27. PMID:35102892<ref>PMID:35102892</ref>


Description: Crystal structure of a betaine aldehyde dehydrogenase from Burkholderia pseudomalei without cofactor
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Seattle Structural Genomics Center For Infectious Disease]]
<div class="pdbe-citations 6wsa" style="background-color:#fffaf0;"></div>
 
==See Also==
*[[Aldehyde dehydrogenase 3D structures|Aldehyde dehydrogenase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Burkholderia pseudomallei 1710b]]
[[Category: Large Structures]]
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