6k8a: Difference between revisions
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==RGLG1 VWA domain with MIDAS is occupied by water== | |||
<StructureSection load='6k8a' size='340' side='right'caption='[[6k8a]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6k8a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K8A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k8a OCA], [https://pdbe.org/6k8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k8a RCSB], [https://www.ebi.ac.uk/pdbsum/6k8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k8a ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RGLG1_ARATH RGLG1_ARATH] E3 ubiquitin-protein ligase that mediates the formation of 'Lys-63'-linked ubiquitin chains. Regulates apical dominance by acting on the auxin transport proteins abundance (PubMed:17586653). Together with RGLG5, mediates the ubiquitination and subsequent proteasomal degradation of the target protein PP2CA. Functions as positive regulator of abscisic acid (ABA) signaling through ABA-dependent degradation of PP2CA, a major inhibitor of ABA signaling (PubMed:27577789). Acts as a negative regulator of drought stress response (PubMed:22095047).<ref>PMID:17586653</ref> <ref>PMID:22095047</ref> <ref>PMID:27577789</ref> | |||
==See Also== | |||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Wang | __TOC__ | ||
[[Category: Wu | </StructureSection> | ||
[[Category: Arabidopsis thaliana]] | |||
[[Category: Large Structures]] | |||
[[Category: Wang Q]] | |||
[[Category: Wu Y]] | |||
Latest revision as of 10:41, 27 March 2024
RGLG1 VWA domain with MIDAS is occupied by water
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