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New page: '''Unreleased structure''' The entry 6xcl is ON HOLD Authors: Description: Category: Unreleased Structures
 
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'''Unreleased structure'''


The entry 6xcl is ON HOLD
==Crystal Structure of human telomeric DNA G-quadruplex in complex with a novel platinum(II) complex.==
<StructureSection load='6xcl' size='340' side='right'caption='[[6xcl]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCL FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=V4A:Platinum(II)+bis[3-(pyridin-2-yl)-[1,2,4]triazolo[4,3-a]pyridine]'>V4A</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcl OCA], [https://pdbe.org/6xcl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcl RCSB], [https://www.ebi.ac.uk/pdbsum/6xcl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcl ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface.


Authors:  
Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.,Miron CE, van Staalduinen L, Rangaswamy AMM, Chen M, Liang Y, Jia Z, Mergny JL, Petitjean A Angew Chem Int Ed Engl. 2020 Oct 22. doi: 10.1002/anie.202012520. PMID:33090592<ref>PMID:33090592</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 6xcl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Jia Z]]
[[Category: Miron CE]]
[[Category: Petitjean A]]
[[Category: Van Staalduinen LM]]
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