6zc7: Difference between revisions

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'''Unreleased structure'''


The entry 6zc7 is ON HOLD  until Paper Publication
==Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling==
 
<StructureSection load='6zc7' size='340' side='right'caption='[[6zc7]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
Authors: Roske, Y., Heinemann, U., Oschkinat, H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[6zc7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZC7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZC7 FirstGlance]. <br>
Description: Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=V31:5-bromanyl-2-[(phenylmethyl)sulfonylamino]benzoic+acid'>V31</scene></td></tr>
[[Category: Oschkinat, H]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zc7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zc7 OCA], [https://pdbe.org/6zc7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zc7 RCSB], [https://www.ebi.ac.uk/pdbsum/6zc7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zc7 ProSAT]</span></td></tr>
[[Category: Heinemann, U]]
</table>
[[Category: Roske, Y]]
== Disease ==
[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DVL3_HUMAN DVL3_HUMAN] Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Heinemann U]]
[[Category: Oschkinat H]]
[[Category: Roske Y]]
Retrieved from "https://proteopedia.org/6zc7"