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| [[5jxg]], [[5jxi]] - hFur - human<br /> | | [[5jxg]], [[5jxi]] - hFur - human<br /> |
| [[4z2a]] - hFur (mutant)<br /> | | [[4z2a]] - hFur (mutant)<br /> |
| [[6eqx]], [[6eqw]], [[6eqv]], [[5jxh]], [[5jxj]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]], [[4ryd]], [[4omc]], [[5omd]] - hFur + peptide inhibitor<br /> | | [[4omc]], [[4omd]], [[4ryd]], [[5jxh]], [[5jxj]], [[6eqv]], [[6eqw]], [[6eqx]], [[6hlb]], [[6hld]], [[6hle]], [[6hza]], [[6hzb]], [[6hzc]], [[6hzd]], [[8b4x]], [[8oyh]] - hFur + peptide inhibitor<br /> |
| [[5mim]] - hFur + inhibitor<br /> | | [[5mim]], [[6yd2]], [[6yd3]], [[6yd4]], [[6yd7]], [[7lcu]], [[7o1u]], [[7o1w]], [[7o1y]], [[7o20]], [[7o22]], [[7qxy]], [[7qxz]], [[7qy0]], [[7qy2]], [[8b4v]], [[8b4w]] - hFur + inhibitor<br /> |
| [[5jmo]] - hFur + antibody<br /> | | [[5jmo]] - hFur + antibody<br /> |
| [[1p8j]] - mFur + peptide inhibitor - mouse<br /> | | [[1p8j]] - mFur + peptide inhibitor - mouse<br /> |
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
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Function
Furin or proprotein convertase furin or dibasic-processing enzyme or paired basic amino acid residue-cleaving enzyme or PACE is a member of the proprotein convertase family and promotes the proteoplytic maturation of proproteins. Furin cleaves precursor proteins at their paired basic amino acid processing sites[1].
Relevance
High furin activity promotes the malignant phenotype of cancer cells in head and neck squamous cell carcinoma, breast cancer and [2]. Furin has a role in atherosclerosis[3]. The new coronavirus SARS-CoV19 genome sequence shows a furin-like cleavage site in the spike protein. This cleavage site has potential implications in the development of antivirals[4]. See SARS-CoV-2 protein S priming by furin, an animation.
- ↑ Thomas G. Furin at the cutting edge: from protein traffic to embryogenesis and disease. Nat Rev Mol Cell Biol. 2002 Oct;3(10):753-66. doi: 10.1038/nrm934. PMID:12360192 doi:https://dx.doi.org/10.1038/nrm934
- ↑ Jaaks P, Bernasconi M. The proprotein convertase furin in tumour progression. Int J Cancer. 2017 Aug 15;141(4):654-663. doi: 10.1002/ijc.30714. Epub 2017 May, 15. PMID:28369813 doi:https://dx.doi.org/10.1002/ijc.30714
- ↑ Ren K, Jiang T, Zheng XL, Zhao GJ. Proprotein convertase furin/PCSK3 and atherosclerosis: New insights and potential therapeutic targets. Atherosclerosis. 2017 Jul;262:163-170. doi:, 10.1016/j.atherosclerosis.2017.04.005. Epub 2017 Apr 7. PMID:28400053 doi:https://dx.doi.org/10.1016/j.atherosclerosis.2017.04.005
- ↑ Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub, 2020 Feb 10. PMID:32057769 doi:https://dx.doi.org/10.1016/j.antiviral.2020.104742
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3D structures of furin
Updated on 07-July-2025
SARS-CoV-2 protein S priming by furin, 5jxi - hFur - human
4z2a - hFur (mutant)
4omc, 4omd, 4ryd, 5jxh, 5jxj, 6eqv, 6eqw, 6eqx, 6hlb, 6hld, 6hle, 6hza, 6hzb, 6hzc, 6hzd, 8b4x, 8oyh - hFur + peptide inhibitor
5mim, 6yd2, 6yd3, 6yd4, 6yd7, 7lcu, 7o1u, 7o1w, 7o1y, 7o20, 7o22, 7qxy, 7qxz, 7qy0, 7qy2, 8b4v, 8b4w - hFur + inhibitor
5jmo - hFur + antibody
1p8j - mFur + peptide inhibitor - mouse
References
