6zy7: Difference between revisions
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New page: '''Unreleased structure''' The entry 6zy7 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Cryo-EM structure of the entire Human topoisomerase II alpha in State 1== | |||
<StructureSection load='6zy7' size='340' side='right'caption='[[6zy7]], [[Resolution|resolution]] 4.64Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[6zy7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZY7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZY7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.64Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=EVP:(5S,5AR,8AR,9R)-9-(4-HYDROXY-3,5-DIMETHOXYPHENYL)-8-OXO-5,5A,6,8,8A,9-HEXAHYDROFURO[3,4 6,7]NAPHTHO[2,3-D][1,3]DIOXOL-5-YL+4,6-O-[(1R)-ETHYLIDENE]-BETA-D-GLUCOPYRANOSIDE'>EVP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zy7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zy7 OCA], [https://pdbe.org/6zy7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zy7 RCSB], [https://www.ebi.ac.uk/pdbsum/6zy7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zy7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TOP2A_HUMAN TOP2A_HUMAN] Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes.<ref>PMID:22323612</ref> | |||
==See Also== | |||
*[[Topoisomerase 3D structures|Topoisomerase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Lamour V]] | |||
[[Category: Vanden Broeck A]] | |||
Latest revision as of 07:43, 1 May 2024
Cryo-EM structure of the entire Human topoisomerase II alpha in State 1
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