Mevalonate kinase: Difference between revisions
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== Function == | == Function == | ||
'''Mevalonate kinase''' (MK) is the first enzyme in the mevalonate pathway which synthesizes sterol isoprenoids like cholesterol and non-sterol isoprenoids like ubiquinone<ref>PMID:17467679</ref>. | '''Mevalonate kinase''' (MK) is the first enzyme in the mevalonate pathway which synthesizes sterol isoprenoids like cholesterol and non-sterol isoprenoids like ubiquinone<ref>PMID:17467679</ref>. MK catalyzes the conversion of mevalonate to 5-phosphomevalonate. | ||
See also [[Mevalonate pathway]] | |||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
The 3D structure of MK complex with mevalonate shows the enzyme composed of <scene name='86/864102/Cv/2'>2 domains</scene>: The N-terminal and the C-terminal. The mevalonate binds in a <scene name='86/864102/Cv/ | The 3D structure of MK complex with mevalonate shows the enzyme composed of <scene name='86/864102/Cv/2'>2 domains</scene>: The N-terminal and the C-terminal. The mevalonate binds in a <scene name='86/864102/Cv/7'>deep cleft</scene> between the 2 domains forming <scene name='86/864102/Cv/6'>H-bonds and hydrophobic interactions</scene><ref>PMID:17397541</ref>. Water molecules are shown as red spheres. | ||
==3D structures of mevalonate kinase== | ==3D structures of mevalonate kinase== | ||
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[[6mdf]] - MmMK + 5-phosphomevalonate<br /> | [[6mdf]] - MmMK + 5-phosphomevalonate<br /> | ||
[[1kkh]], [[1vis]] - MK - ''Methancaldococcus jannaschii''<br /> | [[1kkh]], [[1vis]] - MK - ''Methancaldococcus jannaschii''<br /> | ||
[[8teb]] - MK - ''Methanococcoides burtonii''<br /> | |||
[[8tfo]] - MK + mevalonate - ''Ramazzottius varieornatus''<br /> | |||
[[2oi2]] - MK + diphosphomevalonate - ''Streptococcus pneumaniae''<br /> | [[2oi2]] - MK + diphosphomevalonate - ''Streptococcus pneumaniae''<br /> | ||
[[2hfs]] - LmMK - ''Leishmania major''<br /> | [[2hfs]] - LmMK - ''Leishmania major''<br /> | ||
