7jyd: Difference between revisions
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==Human Liver Receptor Homolog-1 in Complex with 10CA and a Fragment of Tif2== | |||
<StructureSection load='7jyd' size='340' side='right'caption='[[7jyd]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7jyd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JYD FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VQA:10-[(3aR,6R,6aR)-6-hydroxy-3-phenyl-3a-(1-phenylethenyl)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic+acid'>VQA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jyd OCA], [https://pdbe.org/7jyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jyd RCSB], [https://www.ebi.ac.uk/pdbsum/7jyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jyd ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. | |||
==See Also== | |||
*[[Liver receptor homolog-1|Liver receptor homolog-1]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: D'Agostino EH]] | |||
[[Category: Mays SG]] | |||
[[Category: Ortlund EA]] | |||
Latest revision as of 15:14, 18 October 2023
Human Liver Receptor Homolog-1 in Complex with 10CA and a Fragment of Tif2
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