Sphingomyelinase: Difference between revisions
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<StructureSection load='1zwx' size='350' side='right' caption='Sphingomyelinase complex with glycerol and phosphate ion (PDB entry [[21zwx])' scene=''> | <StructureSection load='1zwx' size='350' side='right' caption='Sphingomyelinase complex with glycerol and phosphate ion (PDB entry [[21zwx])' scene=''> | ||
== Function == | == Function == | ||
'''Sphingomyelinase''' (SMase) or '''sphingomyelin phosphodiesterase''' is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and | '''Sphingomyelinase''' (SMase) or '''sphingomyelin phosphodiesterase''' is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and [[Ceramide]]<ref>PMID:11001563</ref>. The SMase is classified into 5 types according to their pH dependence and cation dependence. | ||
*'''Acid SMase-like phosphodiesterase''' is a paralog of '''acid SMase''' and thus though related by gene duplication has different functions. | |||
*'''Acid SMase-like phosphodiesterase 3A''' hydrolyzes nucleotides triphosphates and diphosphates. | |||
*'''Acid SMase-like phosphodiesterase 3B''' is a GPI-anchored protein with role in inflammatory processes and kidney disease<ref>PMID:27687724</ref>. | |||
*'''Alkaline SMase''' hydrolyses sphingomyelin in the intestinal tract and bile<ref>PMID:16631405</ref>. | |||
See also [[Lipid signaling]]. | |||
== Disease == | == Disease == | ||
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*SMase | *SMase | ||
**[[5uvg]] – hSMase catalytic domain – human<br /> | |||
**[[3rlh]], [[3rlg]] – SMase D (mutant) – ''Loxosceles intermedia''<br /> | **[[3rlh]], [[3rlg]] – SMase D (mutant) – ''Loxosceles intermedia''<br /> | ||
**[[1xx1]], [[2f9r]] – SMase I – ''Loxosceles laeta''<br /> | **[[1xx1]], [[2f9r]] – SMase I – ''Loxosceles laeta''<br /> | ||
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**[[2uyr]] – BcSMase (mutant)<br /> | **[[2uyr]] – BcSMase (mutant)<br /> | ||
**[[7cne]] – SMase C – ''Streptomyces griseocarneus''<br /> | **[[7cne]] – SMase C – ''Streptomyces griseocarneus''<br /> | ||
*Acid SMase | *Acid SMase | ||
**[[5jg8]], [[5i81]], [[5i8r]] – hSMase <br /> | |||
**[[5i85]] – hSMase + phosphocholine<br /> | |||
**[[5fib]] – mSMase – mouse<br /> | **[[5fib]] – mSMase – mouse<br /> | ||
**[[5hqn]] – mSMase catalytic domain<br /> | **[[5hqn]] – mSMase catalytic domain<br /> | ||
**[[5fi9]] – mSMase + inhibitor<br /> | **[[5fi9]] – mSMase + inhibitor<br /> | ||
**[[5fic]] – mSMase + lipid<br /> | **[[5fic]] – mSMase + lipid<br /> | ||
*Acid SMase-like phosphodiesterase | *Acid SMase-like phosphodiesterase | ||
**[[5ebb]] – hSMase 3A<br /> | |||
**[[5ebe]] – hSMase 3A + CMP<br /> | |||
**[[5fc1]], [[5fc7]], [[5fca]] – mSMase 3A<br /> | **[[5fc1]], [[5fc7]], [[5fca]] – mSMase 3A<br /> | ||
**[[5fcb]] – mSMase 3A + AMP<br /> | **[[5fcb]] – mSMase 3A + AMP<br /> | ||
**[[5fc6]] – mSMase 3A + AMPCP<br /> | **[[5fc6]] – mSMase 3A + AMPCP<br /> | ||
**[[5fc5]] – mSMase 3A + phosphocholine<br /> | **[[5fc5]] – mSMase 3A + phosphocholine<br /> | ||
**[[5kar]] – mSMase 3B<br /> | **[[5kar]] – mSMase 3B<br /> | ||
**[[5kas]] – mSMase 3B + phosphocholine<br /> | **[[5kas]] – mSMase 3B + phosphocholine<br /> | ||
