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| <StructureSection load='3wca' size='350' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene='59/591996/Cv/1'> | | <StructureSection load='3wca' size='350' side='right' caption='Structure of SQS complex with FPP analog and Mg+2 ions (green) (PDB code [[3wca]]).' scene='59/591996/Cv/1'> |
| | | __TOC__ |
| == Function == | | == Function == |
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| '''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>. '''Dehydrosqualene synthase''' of '''phytene synthase''' catalyzes the condensation of farnesyl diphosphate producing presqualene diphosphate<ref>PMID:21098670</ref>. | | '''Squalene synthase''' (SQS) catalyzes the conversion of 2 molecules of farnesyl pyrophosphate (FPP) to the isoprenoid squalene. SQS is part of the isoprenoid biosynthesis pathway. SQS catalysis is the first step in the sterols synthesis including cholesterol<ref>PMID:11008488</ref>. |
| | *'''Dehydrosqualene synthase''' or '''phytene synthase''' catalyzes the condensation of farnesyl diphosphate producing presqualene diphosphate<ref>PMID:21098670</ref>. |
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| == Relevance == | | == Relevance == |
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| == Structural highlights == | | == Structural highlights == |
| The <scene name='59/591996/Cv/5'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres. | | The <scene name='59/591996/Cv/6'>active site of SQS contains a substrate analog</scene><ref>PMID:24789335</ref>. Water molecules are shown as red spheres. <scene name='59/591996/Cv/7'>Mg coordination site</scene>. |
| </StructureSection> | |
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| ==3D structures of squalene synthase== | | ==3D structures of squalene synthase== |
| | | [[Squalene synthase 3D structures]] |
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *Squalene synthase
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| **[[3vj8]], [[3vjb]] – hSQS – human<br />
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| **[[1ezf]] – hSQS (mutant) <br />
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| **[[4hd1]] – SQS – ''Alicyclobacillus acidocaldarius'' <br />
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| *Squalene synthase complexes
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| **[[3lee]] – hSQS + Mg + bisphosphonate inhibitor<br />
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| **[[3asx]], [[3q2z]], [[3q30]] – hSQS + Mg + PO4 + inhibitor<br />
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| **[[3vj9]], [[3vja]] – hSQS + Ni<br />
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| **[[3vjc]] – hSQS + Mg + PO4 + zaragozic acid<br />
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| **[[3v66]] – hSQS + PO4 + inhibitor<br />
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| **[[3wef]] – hSQS + FPP analog<br />
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| **[[3weg]] – hSQS + Mg + FPP analog<br />
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| **[[3weh]] – hSQS + Mg + presqualene pyrophosphate<br />
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| **[[3wei]] – hSQS (mutant) + Mn + presqualene pyrophosphate<br />
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| **[[3wej]], [[3wek]] – hSQS (mutant) + Mg + presqualene pyrophosphate<br />
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| **[[3wc9]] – hSQS (mutant) + farnesyl thiopyrophosphate<br />
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| **[[3wcd]] – hSQS (mutant) + phenoxy thiocyanate derivative<br />
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| **[[3wcf]], [[3wch]], [[3wci]], [[3wcl]] – hSQS (mutant) + imidazole phosphonate derivative<br />
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| **[[3wcj]] – hSQS (mutant) + pyrrolidine derivative<br />
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| **[[3wcm]] – hSQS (mutant) + pyridine derivative<br />
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| **[[3wsa]], [[3wsb]] – hSQS (mutant) + tuberculosis drug<br />
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| **[[3wef]], [[3weg]] – hSQS + FPP analog <br />
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| **[[3weh]] – hSQS + presqualene pyrophosphate <br />
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| **[[3wei]], [[3wej]], [[3wek]] – hSQS (mutant) + presqualene pyrophosphate <br />
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| **[[3wca]], [[3wcb]], [[3wcc]], [[3wce]], [[3wcg]] – SQS (mutant) + FPP analog – ''Trypanosoma cruzi''<br />
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| *Dehydrosqualene synthase (DSQS)
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| **[[3vjd]], [[2zco]] – SaDSQS – ''Staphylococcus aureus'' <br />
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| **[[3nri]] – SaDSQS + dehydrosqualene <br />
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| **[[3npr]], [[3adz]] – SaSQS + presqualene pyrophosphate <br />
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| **[[3lgz]] – SaSQS (mutant) + presqualene pyrophosphate <br />
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| **[[3vje]] – SaDSQS (mutant) + zaragozic acid <br />
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| **[[3ae0]] – SaDSQS + geranylgeranyl + thiopyrophosphate <br />
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| **[[3w7f]], [[5yis]] – SaDSQS + farnesyl + thiopyrophosphate <br />
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| **[[3acw]], [[3acx]], [[3acy]], [[3tfv]], [[3tfn]], [[3tfp]], [[4f6v]], [[4f6x]], [[2zcs]], [[2zcq]], [[2zy1]], [[2zcr]], [[4e9z]], [[4e9u]], [[4ea0]], [[4ea1]], [[4ea2]] – SaDSQS + inhibitor<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| | | </StructureSection> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
