7dfy: Difference between revisions
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==Novel motif for left-handed G-quadruplex formation== | |||
<StructureSection load='7dfy' size='340' side='right'caption='[[7dfy]], [[Resolution|resolution]] 1.69Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7dfy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DFY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dfy OCA], [https://pdbe.org/7dfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dfy RCSB], [https://www.ebi.ac.uk/pdbsum/7dfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dfy ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation. | |||
A novel minimal motif for left-handed G-quadruplex formation.,Das P, Winnerdy FR, Maity A, Mechulam Y, Phan AT Chem Commun (Camb). 2021 Mar 9;57(20):2527-2530. doi: 10.1039/d0cc08146a. PMID:33690751<ref>PMID:33690751</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7dfy" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Das P]] | |||
[[Category: Maity A]] | |||
[[Category: Mechulam Y]] | |||
[[Category: Phan AT]] | |||
[[Category: Winnerdy FR]] | |||
Latest revision as of 16:32, 29 November 2023
Novel motif for left-handed G-quadruplex formation
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