Chalcone synthase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) New page: <StructureSection load='4mhf' size='340' side='right' caption='DctP complex with glucuronate (PDB code 4mhf)' scene=''> ==Function== '''Chalcone synthase''' is part of the tripartite... |
Michal Harel (talk | contribs) No edit summary |
||
| (14 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load=' | <StructureSection load='1d6h' size='340' side='right' caption='Alfalfa chalcone synthase containing sulfinoalanine complex with CoA and sulfate (PDB code [[1d6h]])' scene='87/873790/Cv/1'> | ||
==Function== | ==Function== | ||
'''Chalcone synthase''' is | '''Chalcone synthase''' (CHS) is essential for the biosynthesis of flavonoids and anthocyanin pigments in plants. CHS condenses p-coumaroyl-CoA and three malonyl-CoA to produce the polyketide naringenin | ||
<ref>PMID:25404490</ref>. | |||
== | ==Relevance== | ||
The CHS biosynthesis product naringenin has inhibitory activity on a Cyt P450 isoform which can have carcinogenic effect <ref>PMID:15744083</ref> and has significant antioxidant properties. | |||
== Structural highlights == | == Structural highlights == | ||
</StructureSection> | <scene name='87/873790/Cv/3'>CoA binding site</scene>. The Cys residue (3-sulfinoalanine is shown in this case) is the catalytic nucleophile tethering the starting group and the growing polyketide chain<ref>PMID:10653632</ref>. Water molecules are shown as red spheres. | ||
== | </StructureSection> | ||
==3D structures of chalcone synthase== | |||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| Line 19: | Line 21: | ||
*Chalcone synthase | *Chalcone synthase | ||
**[[1i88]], [[1i89]], [[1i8b]] - | **[[1bi5]], [[1u0v]] - alCHS 2 - alfalfa<br /> | ||
**[[6dxb]] - | **[[1d6f]], [[1d6i]], [[1i86]], [[1i88]], [[1i89]], [[1i8b]], [[1jwx]] - alCHS 2 (mutant)<br /> | ||
**[[6dxd]] - | **[[6dxb]] - AtCHS - ''Arabidopsis thaliana''<br /> | ||
**[[6dxd]], [[6dxe]] - AtCHS (mutant) <br /> | |||
**[[4wum]] - CHS - freesia<br /> | |||
**[[6dxa]] - CHS - pine<br /> | |||
**[[6dx9]] - CHS - horsetail<br /> | |||
**[[7bus]] - sbCHS - soybean<br /> | |||
**[[6dx7]] - CHS - moss<br /> | |||
**[[5uc5]] - CHS - apple<br /> | |||
**[[4yjy]] - CHS 1 - rice<br /> | |||
**[[8v8n]] - swCHS (mutant) - switchgrass<br /> | |||
**[[6dx8]], [[6dxc]], [[6dxf]] - CHS - ''Selaginella moellendorffii''<br /> | |||
**[[6cqb]] - CHS - kava<br /> | |||
**[[7yj5]] - ScCHS 1 – ''Stenoloma chusanum''<br /> | |||
**[[7vey]] - CpCHS 1 – ''Cyclosorus parasiticus''<br /> | |||
*Chalcone synthase complex | *Chalcone synthase complex | ||
**[[1u0w]] - | **[[1cgk]] - alCHS + naringenin<br /> | ||
**[[1chw]] - | **[[1cgz]] - alCHS + resveratol<br /> | ||
**[[1u0w]] - alCHS 2 (mutant) + resveratol<br /> | |||
**[[1bq6]] - alCHS + CoA<br /> | |||
**[[1d6h]] - alCHS (mutant) + CoA<br /> | |||
**[[1cml]] - alCHS + malonyl-CoA<br /> | |||
**[[1chw]] - alCHS (mutant) + hexanoyl-CoA<br /> | |||
**[[7bur]] - sbCHS + naringenin<br /> | |||
**[[8jrd]] - sbCHS + naringenin + CoA<br /> | |||
**[[8v8m]] - swCHS + naringenin + CoA<br /> | |||
**[[7yj8]] - ScCHS + pinocembrin<br /> | |||
**[[7yja]] - ScCHS + pinocembrin + CoA<br /> | |||
**[[7yj7]] - ScCHS + naringenin<br /> | |||
**[[7yj6]] - ScCHS + CoA<br /> | |||
**[[7yj9]] - ScCHS + naringenin + CoA<br /> | |||
**[[7yjb]] - ScCHS + eriodictyol + CoA<br /> | |||
**[[7vez]] - CpCHS 1 + naringenin <br /> | |||
**[[7vf0]] - CpCHS 1 + naringenin + CoA <br /> | |||
**[[7f08]] - CHS + CoA – ''Abrus precatorius''<br /> | |||
**[[8b32]] - HvCHS + CoA – ''Hordeum vulgare''<br /> | |||
**[[8b3c]] - HvCHS + CoA + eriodictyol <br /> | |||
**[[8b35]] - HvCHS + naringenin + CoA <br /> | |||
}} | |||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Latest revision as of 08:03, 23 January 2025
| ||||||||||||
3D structures of chalcone synthase
Updated on 23-January-2025
