7m40: Difference between revisions
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New page: '''Unreleased structure''' The entry 7m40 is ON HOLD Authors: Perveen, S., Dong, A., Tempel, W., Zepeda-Velazquez, C., Abbey, M., McLeod, D., Marcellus, R., Mohammed, M., Ensan, D., Pan... |
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==Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)== | |||
<StructureSection load='7m40' size='340' side='right'caption='[[7m40]], [[Resolution|resolution]] 1.88Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7m40]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M40 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YQJ:N~3~-{4-[3-(dimethylamino)pyrrolidin-1-yl]-6,7-dimethoxyquinazolin-2-yl}-N~1~,N~1~-dimethylpropane-1,3-diamine'>YQJ</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m40 OCA], [https://pdbe.org/7m40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m40 RCSB], [https://www.ebi.ac.uk/pdbsum/7m40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m40 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> | |||
==See Also== | |||
*[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Abbey M]] | ||
[[Category: Dong | [[Category: Al-awar R]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: Gibson | [[Category: Brown PJ]] | ||
[[Category: | [[Category: Dong A]] | ||
[[Category: | [[Category: Ensan D]] | ||
[[Category: | [[Category: Gibson E]] | ||
[[Category: | [[Category: Marcellus R]] | ||
[[Category: | [[Category: McLeod D]] | ||
[[Category: Schapira | [[Category: Mohammed M]] | ||
[[Category: | [[Category: Panagopoulos D]] | ||
[[Category: | [[Category: Perveen S]] | ||
[[Category: | [[Category: Schapira M]] | ||
[[Category: | [[Category: Tempel W]] | ||
[[Category: Trush V]] | |||
[[Category: Vedadi M]] | |||
[[Category: Zepeda-Velazquez C]] | |||
Latest revision as of 16:05, 18 October 2023
Discovery of small molecule antagonists of human Retinoblastoma Binding Protein 4 (RBBP4)
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