7o2l: Difference between revisions
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New page: '''Unreleased structure''' The entry 7o2l is ON HOLD until Paper Publication Authors: Shi, Y.M., Hirschmann, M., Shi, Y.N., Shabbir, A., Abebew, D., Tobias, N.J., Gruen, P., Crames, J.J... |
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The | ==Yeast 20S proteasome in complex with the covalently bound inhibitor b-lactone (2R,3S)-3-isopropyl-4-oxo-2-oxetane-carboxylate (IOC)== | ||
<StructureSection load='7o2l' size='340' side='right'caption='[[7o2l]], [[Resolution|resolution]] 3.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7o2l]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O2L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O2L FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=V08:(2~{R},3~{S})-3-methanoyl-4-methyl-2-oxidanyl-pentanoic+acid'>V08</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o2l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o2l OCA], [https://pdbe.org/7o2l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o2l RCSB], [https://www.ebi.ac.uk/pdbsum/7o2l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o2l ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | |||
==See Also== | |||
*[[Proteasome 3D structures|Proteasome 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: | [[Category: Abebew D]] | ||
[[Category: | [[Category: Bode H]] | ||
[[Category: | [[Category: Crames JJ]] | ||
[[Category: | [[Category: Groll M]] | ||
[[Category: | [[Category: Gruen P]] | ||
[[Category: | [[Category: Herrmann J]] | ||
[[Category: | [[Category: Hirschmann M]] | ||
[[Category: | [[Category: Kim Y]] | ||
[[Category: | [[Category: Kuttenlochner W]] | ||
[[Category: | [[Category: Mueller R]] | ||
[[Category: | [[Category: Pidot SJ]] | ||
[[Category: | [[Category: Poeschel L]] | ||
[[Category: | [[Category: Richter C]] | ||
[[Category: | [[Category: Shabbir A]] | ||
[[Category: | [[Category: Shi YM]] | ||
[[Category: | [[Category: Shi YN]] | ||
[[Category: | [[Category: Stinear TP]] | ||
[[Category: Thanwisai A]] | |||
[[Category: Tobias NJ]] | |||
Latest revision as of 06:31, 1 October 2025
Yeast 20S proteasome in complex with the covalently bound inhibitor b-lactone (2R,3S)-3-isopropyl-4-oxo-2-oxetane-carboxylate (IOC)
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