7o4d: Difference between revisions
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New page: '''Unreleased structure''' The entry 7o4d is ON HOLD until Paper Publication Authors: Gould, N.L., Scherer, G.R., Carvalh, S., Shurrush, K., Edry, E., Elkobi, A., David, O., Dym, O., Al... |
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==QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline== | |||
<StructureSection load='7o4d' size='340' side='right'caption='[[7o4d]], [[Resolution|resolution]] 2.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7o4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O4D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.249Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V1Z:8-methyl-2-(4-methyl-3-piperazin-1-ylsulfonyl-phenyl)imidazo[1,2-a]pyridine'>V1Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o4d OCA], [https://pdbe.org/7o4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o4d RCSB], [https://www.ebi.ac.uk/pdbsum/7o4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o4d ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Albeck S]] | ||
[[Category: | [[Category: Babaev I]] | ||
[[Category: | [[Category: Barr H]] | ||
[[Category: | [[Category: Carvalh S]] | ||
[[Category: Scherer | [[Category: David O]] | ||
[[Category: | [[Category: Dym O]] | ||
[[Category: | [[Category: Edry E]] | ||
[[Category: Elkobi A]] | |||
[[Category: Germain N]] | |||
[[Category: Gould NL]] | |||
[[Category: Lefker B]] | |||
[[Category: Peleg Y]] | |||
[[Category: Rosenblum K]] | |||
[[Category: Scherer GR]] | |||
[[Category: Sharir H]] | |||
[[Category: Shurrush K]] | |||
[[Category: Subramanyam C]] | |||
