7o5e: Difference between revisions

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'''Unreleased structure'''


The entry 7o5e is ON HOLD
==The structure of an i-motif/duplex junction at neutral pH==
<StructureSection load='7o5e' size='340' side='right'caption='[[7o5e]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O5E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O5E FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DNR:2-DEOXY-N3-PROTONATED+CYTIDINE-5-MONOPHOSPHATE'>DNR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o5e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o5e OCA], [https://pdbe.org/7o5e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o5e RCSB], [https://www.ebi.ac.uk/pdbsum/7o5e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o5e ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report here the three-dimensional structure of an i-motif/duplex junction, determined by NMR methods at neutral pH. By including a minor groove tetrad at one side of the C:C(+) stack of a monomeric i-motif, and a stem/loop hairpin at the other side, we have designed stable DNA constructs in which i-DNA and B-DNA regions coexist in a wide range of experimental conditions. This study demonstrates that i- and B-DNA are structurally compatible, giving rise to a distinctive fold with peculiar groove shapes. The effect of different residues at the i-motif/duplex interface has been explored. We also show that these constructs can be adapted to sequences of biological relevance, like that found in the promoter region of the KRAS oncogene.


Authors:  
Structure of i-Motif/Duplex Junctions at Neutral pH.,Serrano-Chacon I, Mir B, Escaja N, Gonzalez C J Am Chem Soc. 2021 Aug 25;143(33):12919-12923. doi: 10.1021/jacs.1c04679. Epub, 2021 Aug 9. PMID:34370473<ref>PMID:34370473</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 7o5e" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Escaja N]]
[[Category: Gonzalez C]]
[[Category: Mir B]]
[[Category: Serrano-Chacon I]]
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