CD44

spinqualitylabelsall models Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code 2jcq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CD44 is a glycoprotein involved in cell-cell interactions. CD44 is a receptor of hyaluronic acid (HA). CD44 undergoes post-translational modification. Its sialofucosylation changes it to a form which directs migration of stem cells to bone marrow. Binding site of CD44 hyaluronan-binding domain (2jcq). Relevance CD44 is a potential drug target for treatment of malignant neoplasms. Anti-CD44 antibody treatment lowers hyperglycemia and chronic inflammatory diseases.

3D structures of CD44

Updated on 20-January-2025

2jcq, 4pz4 – hCD44 hyaluronan-binding domain 18-171 – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
4pz3 - hCD44 hyaluronan-binding domain + tetrapeptide
2jcp - mCD44 hyaluronan-binding domain 23-172 – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, , 4np3, 5bzc, 5bzk, 5sbk, 5sbl, 5sbm, 5sbn, 5sbo, 5sbp, 5sbq, 5sbr, 5sbs, 5sbt, 5sbu, 5sbv, 5sbw, 5sbx, 5sby, 5sbz, 5sc0, 5sc1, 5sc2, 5sc3, 5sc4, 5sc5, 5sc6, 5sc7 - mCD44 hyaluronan-binding domain + inhibitor
5bze, 5bzf, 5bzg, 5bzh, 5bzi, 5bzj, 5bzl, 5bzm, 5bzn, 5bzo, 5bzp, 5bzq, 5bzr, 5bzs, 5bzt - mCD44 hyaluronan-binding domain (mutant) + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide

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