7on0: Difference between revisions
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==Thermus sp. 2.9 DarT in complex with ADP-ribosylated ssDNA== | |||
<StructureSection load='7on0' size='340' side='right'caption='[[7on0]], [[Resolution|resolution]] 1.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7on0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_sp._2.9 Thermus sp. 2.9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ON0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ON0 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7on0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7on0 OCA], [https://pdbe.org/7on0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7on0 RCSB], [https://www.ebi.ac.uk/pdbsum/7on0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7on0 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DART_THES0 DART_THES0] Toxic component of a hybrid type II/IV toxin-antitoxin (TA) system. ADP-ribosylates ssDNA on the second thymidine of the consensus sequence 5'-TNTC-3'; the protein does not auto-modify. Arg-51 is highly flexible, allowing it to assume multiple positions in the crystal structures (PubMed:34408320). Its toxic effect is neutralized by cognate antitoxin DarG (By similarity).[UniProtKB:O53604]<ref>PMID:34408320</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Thermus sp. 2 9]] | |||
[[Category: Ariza A]] | |||
[[Category: Schuller M]] | |||
Latest revision as of 07:51, 1 May 2024
Thermus sp. 2.9 DarT in complex with ADP-ribosylated ssDNA
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