Fibroblast growth factor: Difference between revisions
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'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family<ref>PMID:11276432</ref>. <br /> | '''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family<ref>PMID:11276432</ref>. <br /> | ||
* '''FGF1''' is called acidic FGF.<br /> | * '''FGF1''' is called acidic FGF.<br /> | ||
* '''FGF2''' is called basic FGF.<br /> | * '''FGF2''' is called basic FGF. See also [[API5-FGF2 complex]].<br /> | ||
* '''FGF4''' has multiple roles during vertebrate embryogenesis<ref>PMID:18792115</ref>.<br /> | * '''FGF4''' has multiple roles during vertebrate embryogenesis<ref>PMID:18792115</ref>.<br /> | ||
* '''FGF7''' is called keratinocyte growth factor which is present in the epitheliazation-phase of wound healing when keratinocytes are covering the wound<ref>PMID:11052999</ref>. FGF7 is aparacrine growth factor in the breast<ref>PMID:12697038</ref>. | * '''FGF7''' is called '''keratinocyte growth factor''' which is present in the epitheliazation-phase of wound healing when keratinocytes are covering the wound<ref>PMID:11052999</ref>. FGF7 is aparacrine growth factor in the breast<ref>PMID:12697038</ref>. | ||
* '''FGF8''' has multiple roles in the regulation of embryogenesis, cell differentiation, proliferation and migration. It is required for normal development of normal brain, eye, ear and limb<ref>PMID:22273727</ref>.<br /> | * '''FGF8''' has multiple roles in the regulation of embryogenesis, cell differentiation, proliferation and migration. It is required for normal development of normal brain, eye, ear and limb<ref>PMID:22273727</ref>.<br /> | ||
* '''FGF9''' is produced and secreted by the prostatic stromal cells<ref>PMID:10362017</ref>.<br /> | * '''FGF9''' is produced and secreted by the prostatic stromal cells<ref>PMID:10362017</ref>.<br /> | ||
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* '''FGF12''' is a key regulator of the vascular smooth muscle cell phenotype switch<ref>PMID:27470512</ref>.<br /> | * '''FGF12''' is a key regulator of the vascular smooth muscle cell phenotype switch<ref>PMID:27470512</ref>.<br /> | ||
* '''FGF13''' regulates proliferation and differentiation of the skeletal muscle cells <ref>PMID:26230950</ref>.<br /> | * '''FGF13''' regulates proliferation and differentiation of the skeletal muscle cells <ref>PMID:26230950</ref>.<br /> | ||
* '''FGF18''' has al role in organ development and damage repair <ref>PMID:36871047</ref>.<br /> | |||
* '''FGF19''' has high affinity to FGFR4<ref>PMID:10525310</ref>.<br /> | |||
* '''FGF21''' has a role in regulating body weight in a dietary carbohydrate-dependent manner <ref>PMID:37030441</ref>.<br /> | |||
* '''FGF23''' is produced by bone cells and regulates renal phosphate and vitamin D metabolism <ref>PMID:29760049</ref>.<br /> | * '''FGF23''' is produced by bone cells and regulates renal phosphate and vitamin D metabolism <ref>PMID:29760049</ref>.<br /> | ||
See also [[Fibroblast growth factor receptor]] and [[Growth factors]]. | See also [[Fibroblast growth factor receptor]] and [[Growth factors]]. | ||
