7rsi: Difference between revisions

Latest revision as of 05:48, 5 June 2024

The cryo-EM map of KIF18A bound to KIFBP

Structural highlights

7rsi is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 4.9Å
Ligands:	ADP, MG
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

KBP_HUMAN Goldberg-Shprintzen megacolon syndrome. The disease is caused by variants affecting the gene represented in this entry.

Function

KBP_HUMAN Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.^[1] ^[2] ^[3]

Publication Abstract from PubMed

[Figure: see text].

Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding.,Solon AL, Tan Z, Schutt KL, Jepsen L, Haynes SE, Nesvizhskii AI, Sept D, Stumpff J, Ohi R, Cianfrocco MA Sci Adv. 2021 Nov 19;7(47):eabj9812. doi: 10.1126/sciadv.abj9812. Epub 2021 Nov, 19. PMID:34797717^[4]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Wozniak MJ, Melzer M, Dorner C, Haring HU, Lammers R. The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein. BMC Cell Biol. 2005 Oct 14;6:35. doi: 10.1186/1471-2121-6-35. PMID:16225668 doi:https://dx.doi.org/10.1186/1471-2121-6-35
↑ Alves MM, Burzynski G, Delalande JM, Osinga J, van der Goot A, Dolga AM, de Graaff E, Brooks AS, Metzger M, Eisel UL, Shepherd I, Eggen BJ, Hofstra RM. KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Hum Mol Genet. 2010 Sep 15;19(18):3642-51. doi: 10.1093/hmg/ddq280. Epub 2010 Jul, 9. PMID:20621975 doi:https://dx.doi.org/10.1093/hmg/ddq280
↑ Drevillon L, Megarbane A, Demeer B, Matar C, Benit P, Briand-Suleau A, Bodereau V, Ghoumid J, Nasser M, Decrouy X, Doco-Fenzy M, Rustin P, Gaillard D, Goossens M, Giurgea I. KBP-cytoskeleton interactions underlie developmental anomalies in Goldberg-Shprintzen syndrome. Hum Mol Genet. 2013 Jun 15;22(12):2387-99. doi: 10.1093/hmg/ddt083. Epub 2013 Feb, 19. PMID:23427148 doi:https://dx.doi.org/10.1093/hmg/ddt083
↑ Solon AL, Tan Z, Schutt KL, Jepsen L, Haynes SE, Nesvizhskii AI, Sept D, Stumpff J, Ohi R, Cianfrocco MA. Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Sci Adv. 2021 Nov 19;7(47):eabj9812. doi: 10.1126/sciadv.abj9812. Epub 2021 Nov, 19. PMID:34797717 doi:https://dx.doi.org/10.1126/sciadv.abj9812

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OCA

[1] Wozniak MJ, Melzer M, Dorner C, Haring HU, Lammers R. The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein. BMC Cell Biol. 2005 Oct 14;6:35. doi: 10.1186/1471-2121-6-35. PMID:16225668 doi:https://dx.doi.org/10.1186/1471-2121-6-35

[2] Alves MM, Burzynski G, Delalande JM, Osinga J, van der Goot A, Dolga AM, de Graaff E, Brooks AS, Metzger M, Eisel UL, Shepherd I, Eggen BJ, Hofstra RM. KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Hum Mol Genet. 2010 Sep 15;19(18):3642-51. doi: 10.1093/hmg/ddq280. Epub 2010 Jul, 9. PMID:20621975 doi:https://dx.doi.org/10.1093/hmg/ddq280

[3] Drevillon L, Megarbane A, Demeer B, Matar C, Benit P, Briand-Suleau A, Bodereau V, Ghoumid J, Nasser M, Decrouy X, Doco-Fenzy M, Rustin P, Gaillard D, Goossens M, Giurgea I. KBP-cytoskeleton interactions underlie developmental anomalies in Goldberg-Shprintzen syndrome. Hum Mol Genet. 2013 Jun 15;22(12):2387-99. doi: 10.1093/hmg/ddt083. Epub 2013 Feb, 19. PMID:23427148 doi:https://dx.doi.org/10.1093/hmg/ddt083

[4] Solon AL, Tan Z, Schutt KL, Jepsen L, Haynes SE, Nesvizhskii AI, Sept D, Stumpff J, Ohi R, Cianfrocco MA. Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding. Sci Adv. 2021 Nov 19;7(47):eabj9812. doi: 10.1126/sciadv.abj9812. Epub 2021 Nov, 19. PMID:34797717 doi:https://dx.doi.org/10.1126/sciadv.abj9812

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7rsi is ON HOLD
+==The cryo-EM map of KIF18A bound to KIFBP==
+<StructureSection load='7rsi' size='340' side='right'caption='[[7rsi]], [[Resolution|resolution]] 4.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7rsi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RSI FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rsi OCA], [https://pdbe.org/7rsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rsi RCSB], [https://www.ebi.ac.uk/pdbsum/7rsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rsi ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/KBP_HUMAN KBP_HUMAN] Goldberg-Shprintzen megacolon syndrome. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/KBP_HUMAN KBP_HUMAN] Required for organization of axonal microtubules, and axonal outgrowth and maintenance during peripheral and central nervous system development.<ref>PMID:16225668</ref> <ref>PMID:20621975</ref> <ref>PMID:23427148</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+[Figure: see text].
-Authors: Tan, Z., Solon, A.L., Schutt, K.L., Jepsen, L., Haynes, S.E., Nesvizhskii, A.I., Sept, D., Stumpff, J., Ohi, R., Cianfrocco, M.A.
+Kinesin-binding protein remodels the kinesin motor to prevent microtubule binding.,Solon AL, Tan Z, Schutt KL, Jepsen L, Haynes SE, Nesvizhskii AI, Sept D, Stumpff J, Ohi R, Cianfrocco MA Sci Adv. 2021 Nov 19;7(47):eabj9812. doi: 10.1126/sciadv.abj9812. Epub 2021 Nov, 19. PMID:34797717<ref>PMID:34797717</ref>
-Description: The cryo-EM map of KIF18A bound to KIFBP
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Schutt, K.L]]
+<div class="pdbe-citations 7rsi" style="background-color:#fffaf0;"></div>
-[[Category: Sept, D]]
-[[Category: Stumpff, J]]
+==See Also==
-[[Category: Haynes, S.E]]
+*[[Kinesin 3D Structures|Kinesin 3D Structures]]
-[[Category: Jepsen, L]]
+== References ==
-[[Category: Solon, A.L]]
+<references/>
-[[Category: Nesvizhskii, A.I]]
+__TOC__
-[[Category: Ohi, R]]
+</StructureSection>
-[[Category: Tan, Z]]
+[[Category: Homo sapiens]]
-[[Category: Cianfrocco, M.A]]
+[[Category: Large Structures]]
+[[Category: Cianfrocco MA]]
+[[Category: Haynes SE]]
+[[Category: Jepsen L]]
+[[Category: Nesvizhskii AI]]
+[[Category: Ohi R]]
+[[Category: Schutt KL]]
+[[Category: Sept D]]
+[[Category: Solon AL]]
+[[Category: Stumpff J]]
+[[Category: Tan Z]]

7rsi: Difference between revisions

Latest revision as of 05:48, 5 June 2024

The cryo-EM map of KIF18A bound to KIFBP

Structural highlights

Disease

Function

Publication Abstract from PubMed

See Also

References

Contents

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