Integrin 3D structures: Difference between revisions

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*IG CR3
*IG CR3


**[[1ido]] – hIG I domain + Mg – human<br />
**[[1ido]] – hIG I domain + Mg – human
**[[1jlm]] - hIG I domain + Mn<br />
**[[1jlm]] - hIG I domain + Mn


*IG α-1


 
**[[4a0q]] - hIG I domain 166-366 (mutant) + Mg
*''IG CD11a complexes''
**[[2l8s]] - hIG transmembrane domain 1135-1179 – NMR<BR />
 
**[[1cqp]] - hIG I domain + lovastatin + Mg<br />
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg<br />
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
**[[1xdd]], [[1xdg]], [[1xuo]] - hIG I domain + inhibitor + Mg<br />
**[[4ixd]] - hIG I domain + activator + Mg<br />
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 
*IG CD11b I domain 143-337 or IG α-M
 
**[[1idn]], [[1na5]] - hIG<br />
**[[1mf7]] - hIG (mutant)<br />
**[[1bho]] - hIG + Mg<br />
**[[1bhq]] - hIG + Cd<br />
**[[1m1u]] - hIG (mutant) + Ca<br />
**[[1n9z]] - hIG (mutant) + Mg<br />
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
**[[4m76]] – hIG + complement C3<br />
**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<br />
**[[4xw2]] – hIG + simvastatin<br />
**[[6rhv]], [[6rhw]] – hIG + cytolysin<br />
 
*IG CD11c
 
**[[1n3y]] - hIG I domain (mutant)
 
*IG α-1 (CD49a)
 
**[[4a0q]] - hIG I domain (mutant) + Mg<br />
**[[2l8s]] - hIG transmembrane domain – NMR<BR />
**[[5hgj]] - hIG VWFA domain<br />
**[[5hgj]] - hIG VWFA domain<br />
**[[2m32]] - hIG I domain + collagen peptide<br />
**[[2m32]] - hIG I domain + collagen peptide<br />
**[[1ck4]] - rIG I domain – rat<br />
**[[1ck4]] - rIG I domain – rat
**[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br />
**[[1mhp]] - rIG I domain (mutant) + antibody + Mn
**[[2b2x]] - rIG I domain (mutant) + antibody + Mg<br />
**[[2b2x]] - rIG I domain (mutant) + antibody + Mg


*IG α-2 (CD49b)
*IG α-2


**[[4bj3]], [[5e6x]], [[5e6v]] - hIG I domain<br />
**[[4bj3]], [[5e6v]], [[5e6x]] - hIG I domain<br />
**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
**[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide
**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
**[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn
**[[5thp]], [[6nd8]], [[6nd9]], [[6nda]], [[6ndb]], [[6ndc]], [[6ndd]], [[6nde]], [[6ndf]], [[6ndg]], [[6ndh]] - hIG residues 170-366 + rhodocetin <br />
**[[5thp]], [[6nd8]], [[6nd9]], [[6nda]], [[6ndb]], [[6ndc]], [[6ndd]], [[6nde]], [[6ndf]], [[6ndg]], [[6ndh]] - hIG residues 170-366 + rhodocetin <br />


*IG α-2b
*IG α-1 + IG β-1


**[[2k1a]] - hIG transmembrane domain – NMR<BR />
**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg
 
**[[1pt6]] - hIG I domain + Mg
*IG α-1 β-1 (CD49a-CD49b)
 
**[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br />
**[[1pt6]] - hIG I domain + Mg<br />


*IG α-2 (CD49b) β
*IG α-2 + IG β


**[[5hj2]] - hIG I domain<br />
**[[5hj2]] - hIG I domain<br />
**[[1aox]] - hIG I domain (mutant) + Mg<br />
**[[1aox]] - hIG I domain (mutant)  
**[[2k1a]] - hIG transmembrane domain – NMR<br />
**[[2k1a]] - hIG transmembrane domain – NMR<BR />


*IG α-2b β-3 (CD61)
*IG α-2b + IG β-3


**[[4cak]], [[8gcd]], [[8gce]], [[8t2v]], [[9dax]] – hIG – Cryo EM<br />
**[[8t2u]] – hIG + drug – Cryo EM<br />
**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
**[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR />
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
**[[1m8o]] - hIG cytoplasmic domain – NMR<BR />
**[[4cak]] – hIG – Cryo-EM<br />
**[[2k9j]], [[2knc]], [[7kn0]] - hIG transmembrane domain – NMR<BR />
**[[2k9j]], [[2knc]] - hIG transmembrane domain – NMR<BR />
**[[1tye]], [[3fcs]], [[3fcu]] – hIG + Mg
**[[1tye]], [[3fcu]], [[3fcs]] – hIG + Mg<br />
**[[3fc3]] – hIG (mutant) + Mg
**[[3fc3]] – hIG (mutant) + Mg<br />
**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]], [[5hdb]] – hIG headpiece + antibody + Mg
**[[2vc2]], [[2vdk]], [[2vdl]], [[3nid]], [[3nif]], [[3nig]], [[3zdx]], [[3zdy]], [[3zdz]], [[3ze0]], [[3ze1]], [[3ze2]], [[5hdb]] – hIG headpiece + antibody + Mg<br />
**[[4z7n]], [[4z7o]], [[4z7q]] – hIG headpiece + antibody + Mg + tetrapeptide<br />
**[[4z7q]], [[4z7o]], [[4z7n]] – hIG headpiece + antibody + Mg + tetrapeptide<br />
**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg
**[[2vdm]], [[2vdn]], [[3t3m]], [[3t3p]] – hIG headpiece + antibody + antagonist + Mg<br />
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg
**[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br />
**[[6v4p]], [[7la4]], [[9axl]], [[9dao]] – hIG + antibody – Cryo-EM<br />
**[[6v4p]] – hIG + antibody – Cryo-EM<br />
**[[9deq]], [[9der]] – hIG + drug – Cryo-EM<br />
**[[7l8p]], [[7tct]], [[7td8]], [[7tho]], [[7tmz]], [[7tpd]], [[7u60]], [[7u9f]], [[7u9v]], [[7ubr]], [[7ucy]], [[7udg]], [[7udh]], [[7ue0]], [[7ufh]], [[7uh8]], [[7uje]], [[7ujk]], [[7uk9]], [[7uko]], [[7ukp]], [[7ukt]] – hIG + antibody + drug<br />
 
*IG α-4


*IG α-4
**[[4irz]] - hIG + antibody <br />
**[[4irz]] - hIG + antibody <br />


*IG α-4 (CD49d) β-7
*IG α-4 + IG β-7


**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br />
**[[3v4p]] - hIG headpiece (mutant) + antibody + Mg
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br />
**[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg


*IG α-5 (CD49e) β-1 (CD29)
*IG α-5 + IG β-1


**[[7nxd]] – hIG + Mg – Cryo-EM<br />
**[[7nwl]] – hIG + fibronectin + laminin – Cryo-EM<br />
**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
**[[4wjk]] - hIG headpiece (mutant) + Mg<br />
**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
**[[4wk0]], [[4wk2]], [[4wk4]] - hIG headpiece (mutant) + peptide + Mg<br />
**[[3vi3]] - hIG headpiece + antibody + Mg<br />
**[[9b9j]], [[9b9k]], [[9nab]] – hIG + antibody – Cryo-EM<br />
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br />
**[[9ckv]], [[9dia]], [[9ef2]] – hIG + NeoNectin – Cryo-EM<br />
**[[3vi3]] - hIG headpiece + antibody + Mg
**[[3vi4]] - hIG headpiece + antibody + peptide + Mg
**[[8oxz]] - rIG headpiece – Cryo EM<br />


*IG α-5 (CD49e) β-3 (CD61) ectodomain
*IG α-5 + IG β-3 ectodomain


**[[3ije]], [[1m1x]], [[4g1e]], [[4g1m]], [[1u8c]] – hIG + cation<br />
**[[1m1x]], [[1u8c]], [[3ije]], [[4g1e]], [[4g1m]] – hIG + cation
**[[4mmx]], [[4mmy]], [[4mmz]] - hIG + Mn + fibronectin domain 10<br />
**[[4mmx]], [[4mmy]], [[4mmz]] - hIG + Mn + fibronectin domain 10<br />
**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG + antibody<br />
**[[4o02]], [[6avq]], [[6avr]], [[6avu]] - hIG + antibody<br />
**[[1jv2]] - hIG + platelet membrane glycoprotein IIIA + Ca<br />
**[[1jv2]] - hIG + platelet membrane glycoprotein IIIA + Ca
**[[1l5g]] - hIG + tripeptide + Mn<br />
**[[1l5g]] - hIG + tripeptide + Mn


*IG α-5 β-6
*IG α-5 + IG β-6


**[[4um8]] – hIG headpiece (mutant) + Ni<br />
**[[4um8]] – hIG headpiece (mutant) + Ni<br />
**[[5ffg]] – hIG headpiece + Ca<br />
**[[5ffg]] – hIG headpiece + Ca<br />
**[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β  3<br />
**[[4um9]], [[5ffo]] – hIG headpiece (mutant) + Mg + transforming growth factor β  3<br />
**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
**[[5nem]], [[5ner]], [[5net]], [[5neu]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
*IG α-6 + IG β-1
**[[7ceb]], [[7cec]] – hIG headpiece + laminin + Mg<br />
*IG α-E + IG β-7
**[[8zjf]] – hIG – Cryo EM<br />


*IG α-L
*IG α-L


**[[4ixd]] – hIG I domain<br />
**[[1lfa]] - hIG I domain + Mn <br />
**[[1zon]], [[4ixd]], [[7kc3]] - hIG I domain 153-334 <br />
**[[1mqa]] - hIG I domain (mutant) <br />
**[[1zoo]], [[1zop]], [[3f74]] - hIG I domain + Mg <br />
**[[1mq9]] - hIG I domain (mutant) + Mn <br />
**[[1mjn]] - hIG I domain (mutant) + Mg <br />
**[[2k8o]] – hIG cytoplasmic domain (mutant) – NMR<BR /> <br />
**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
**[[5e6s]], [[5e6r]] – hIG AI, headpiece,pocket domains + Mg<br />
**[[2m3e]] – hIG transmembrane domain - NMR<br />
**[[2m3e]] – hIG transmembrane domain - NMR<BR /><br />


*IG α-L β-2
*IG α-L complexes
 
**[[1cqp]] - hIG I domain + lovastatin + Mg <br />
**[[1mq8]], [[3bn3]], [[3tcx]] - hIG I domain (mutant) + intracellular adhesion molecule + Mg <br />
**[[1t0p]] - hIG I domain + intracellular adhesion molecule-3 + Mg<br />
**[[1rd4]], [[2ica]], [[3bqm]], [[3bqn]], [[3e2m]] - hIG I domain + inhibitor<br />
**[[2o7n]], [[3m6f]] - hIG I domain + antagonist<br />
**[[1xdd]], [[1xdg]], [[1xuo]], [[7kc5]] - hIG I domain + inhibitor + Mg<br />
**[[7kc6]] - hIG I domain + drug + Mg<br />
**[[3f78]] - hIG I domain + anesthetic + Mg<br />
**[[3eoa]], [[3eob]] - hIG I domain + antibody<br />
**[[3hi6]] - hIG I domain (mutant) + antibody + Mn<br />
 
*IG α-L + IG β-2


**[[5e6u]] – hIG headpiece (mutant) + Ni<br />
**[[5e6u]] – hIG headpiece (mutant) + Ni<br />


*IG α-V β-3
*IG α-M
 
**[[1idn]], [[1na5]] - hIG<br />
**[[1mf7]] - hIG (mutant) <br />
**[[1bho]] - hIG + Mg<br />
**[[1bhq]] - hIG + Cd<br />
**[[1m1u]] - hIG (mutant) + Ca<br />
**[[1n9z]] - hIG (mutant) + Mg<br />
**[[3q3g]], [[3qa3]] – hIG + antibody<br />
**[[4m76]] – hIG + complement C3<br />
**[[2lke]], [[2lkj]] – hIG cytoplasmic domain – NMR<BR /><br />
**[[8voh]], [[8voi]] – hIG I domain + pleiotrophin – NMR<BR /><br />
**[[4xw2]] – hIG + simvastatin<br />
**[[6rhv]], [[6rhw]] – hIG + cytolysin<br />
 
*IG α-M + IG β-2
 
**[[7usm]] – hIG ectodomain – Cryo EM<br />
**[[7usl]] – hIG ectodomain + adenylate cyclase toxin + antibody – Cryo EM<br />
**[[7p2d]] – hIG ectodomain + nanobody <br />


*IG α-V + IG β-1
**[[8w30]] – hIG headpiece + inhibitor<br />
*IG α-V + IG β-3
**[[8ij5]], [[8xei]], [[8xek]], [[8xen]], [[8xez]] – hIG – Cryo EM<br />
**[[8xer]], [[8xf6]], [[8xfg]], [[8xfo]], [[9jei]] – hIG + drug – Cryo EM<br />
**[[9iuj]] - hIG + rhodostomin – Cryo EM<br />
**[[6mk0]] – hIG + antagonist<br />
**[[6mk0]] – hIG + antagonist<br />
**[[6msl]] – hIG + cysteine knot protein<br />
**[[6msl]] – hIG + cysteine knot protein<br />
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**[[6naj]] – hIG + fibronectin<br />
**[[6naj]] – hIG + fibronectin<br />


*IG α-V β-8
*IG α-V + IG β-6
 
**[[8tcf]], [[8tcg]] – hIG + miniprotein inhibitor – Cryo EM<br />
**[[9cz7]], [[9cza]], [[9czd]], [[9czf]] – hIG + antibody – Cryo EM<br />


**[[6djp]], [[6ujb]], [[6ujc]] – hIG + antibody – Cryo EM<br />
*IG α-V + IG β-8
 
**[[6djp]], [[6ujb]], [[6ujc]], [[9ind]] – hIG + antibody – Cryo EM<br />
**[[6om1]] – hIG (mutant)<br />
**[[6om1]] – hIG (mutant)<br />
**[[6om2]] – hIG (mutant) + Protgf-b1 RGD peptide<br />
**[[6om2]] – hIG (mutant) + Protgf-b1 RGD peptide<br />
**[[6uja]] – hIG + Protgf-b1 RGD – Cryo EM<br />
**[[6uja]] – hIG + Protgf-b1 RGD – Cryo EM<br />
**[[7y1t]], [[8vs6]], [[8vsd]] – hIG + TGF-b1 – Cryo EM<br />


*IG α-X
*IG α-X


**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
**[[2luv]] – hIG cytoplasmic domain – NMR<BR />
**[[1n3y]] – hIG domain I (mutant)<br />


*IG α-X β-2 (CD18)
*IG α-X + IG β-2


**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg<br />
**[[3k6s]], [[3k71]], [[3k72]], [[5es4]] – hIG + Mg
**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />
**[[4neh]], [[4nen]] – hIG (mutant) + Mg<br />
*IG β-1
**[[8rpq]] - hIG transmembrane domain 726-761 – NMR<BR />


*IG β-1D
*IG β-1D
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**[[3g9w]] – hIG cytoplasmic tail + talin 2 F2-F3 domain<br />
**[[3g9w]] – hIG cytoplasmic tail + talin 2 F2-F3 domain<br />


*IG β-2 (CD18)
*IG β-2


**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />
**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains
**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />
**[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />
**[[5zaz]] – hIG transmembrane domain - NMR<br />
**[[5zaz]] – hIG transmembrane domain - NMR<BR />


*IG β-3 (CD61)
*IG β-3


**[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR />
**[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR />
Line 170: Line 207:
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2l1c]] – hIG cytoplasmic tail + SHC<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
**[[2mtp]] – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain<br />
**[[6bxb]], [[6bxf]] – hIG/hIG α-L <br />


*IG β-4 (CD104; Gp150)
*IG β-4 or Gp150


**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain<br />
**[[2f7q]], [[3f7r]], [[1qg3]], [[3f7q]], [[4wtw]], [[4wtx]] - hIG fibronectin type III domain
**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />
**[[2yrz]] – hIG fibronectin type III domain – NMR<BR />
**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1 <br />
**[[3f7p]], [[4q58]] - hIG fibronectin type III domain + plectin-1  
**[[6gvl]] - hIG fibronectin type III domain + dystonin<br />
**[[6gvl]] - hIG fibronectin type III domain + dystonin<br />
**[[6gvk]] - hIG fibronectin type III domain (mutant) + dystonin<br />
**[[6gvk]] - hIG fibronectin type III domain (mutant) + dystonin<br />
**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain<br />
**[[3fq4]], [[3fso]], [[3h6a]] – hIG Calx-β domain
**[[6hyf]] - rIG fibronectin type III domain <br />
**[[6hyf]] - rIG fibronectin type III domain <br />


*IG β-7
*IG β-7


**[[2brq]], [[2jf1]] – hIG cytoplasmic tail + filamin rod domain<br />
**[[2brq]], [[2jf1]] – hIG cytoplasmic tail + filamin rod domain<br />  


}}
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[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 09:39, 25 September 2025

3D structures of integrin

Updated on 25-September-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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