Corticosteroids: Difference between revisions
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New page: <StructureSection load='' size='350' side='right' caption='FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry 1h61)' scene='49/490063/Cv/1'> This ... |
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<StructureSection load='' size='350' side='right' caption='FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry [[1h61]])' scene='49/490063/Cv/1'> | <StructureSection load='' size='350' side='right' caption='FMN containing pentaerythritol tetranitrate reductase complex with prednisone (PDB entry [[1h61]])' scene='49/490063/Cv/1'> | ||
Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex of vertebrates, as well as the synthetic analogues of these hormones. Two main classes of corticosteroids, [[glucocorticoids]] and [[mineralocorticoids]], are involved in a wide range of physiological processes. | |||
= | <scene name='89/896210/Cv/1'>Prednisone</scene> and its derivatives have some mineralocorticoid action in addition to the glucocorticoid effect. | ||
= | <scene name='89/895670/Cv/2'>Cortisol</scene> (hydrocortisone) is a corticosteroid with both glucocorticoid and mineralocorticoid activity and effects. | ||
== | <scene name='89/895670/Cv/3'>Dexamethasone</scene> is a glucocorticoid medication. It is the most potent glucocorticoid and it has not mineralocorticoid potency. <scene name='89/895670/Cv/4'>Human glucocorticoid receptor ligand-binding domain bound to dexamethasone</scene> ([[1m2z]]). | ||
*[[Glucocorticoids]] | |||
*[[Mineralocorticoids]] | |||
*[[Pentaerythritol tetranitrate reductase]] active site contains the cofactor <scene name='49/490063/Cv/5'>FMN</scene> and the <scene name='49/490063/Cv/6'>substrate steroid prednisone</scene><ref>PMID:11428899</ref>. Water molecules are shown as red spheres. <scene name='49/490063/Cv/7'>Whole active site</scene>. | |||
*[[Corticosteroid-binding globulin]] | |||
</StructureSection> | </StructureSection> | ||
See also: | |||
*[[Steroid Hormones and their receptors]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Latest revision as of 11:16, 14 November 2021
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See also:
