7t7s: Difference between revisions
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==R-27 in Complex with S. aureus DHFR and tricyclic-NADPH (tNADPH)== | |||
<StructureSection load='7t7s' size='340' side='right'caption='[[7t7s]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7t7s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T7S FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=06U:6-ETHYL-5-{(3R)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06U</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=XNP:TRICYCLIC+NADPH'>XNP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t7s OCA], [https://pdbe.org/7t7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t7s RCSB], [https://www.ebi.ac.uk/pdbsum/7t7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t7s ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus]] | |||
[[Category: Donald BR]] | |||
[[Category: Reeve SM]] | |||
[[Category: Wang S]] | |||
[[Category: Wright DL]] | |||
Latest revision as of 10:10, 16 August 2023
R-27 in Complex with S. aureus DHFR and tricyclic-NADPH (tNADPH)
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