7t5m: Difference between revisions
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==Structure of HLA-A*02:01-FLPTPEELGLLGPPRPQVLA complex== | |||
<StructureSection load='7t5m' size='340' side='right'caption='[[7t5m]], [[Resolution|resolution]] 1.67Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7t5m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T5M FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t5m OCA], [https://pdbe.org/7t5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t5m RCSB], [https://www.ebi.ac.uk/pdbsum/7t5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t5m ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q861F7_HUMAN Q861F7_HUMAN] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Unconventional HLA class I-restricted CD8(+) T cell epitopes, longer than 10 aa, have been implicated to play a role in human immunity against viruses and cancer. T cell recognition of long peptides, centrally bulging from the HLA cleft, has been described previously. Alternatively, long peptides can contain a linear HLA-bound core peptide, with a N- or C-terminal peptide "tail" extending from the HLA peptide binding groove. The role of such a peptide "tail" in CD8(+) T cell recognition remains unclear. In this study, we identified a 20mer peptide (FLPTPEELGLLGPPRPQVLA [FLP]) derived from the IL-27R subunit alpha gene restricted to HLA-A*02:01, for which we solved the crystal structure and demonstrated a long C-terminal "tail" extension. FLP-specific T cell clones demonstrated various recognition modes, some T cells recognized the FLP core peptide, while for other T cells the peptide tail was essential for recognition. These results demonstrate a crucial role for a C-terminal peptide tail in immunogenicity. | |||
Cutting Edge: Unconventional CD8(+) T Cell Recognition of a Naturally Occurring HLA-A*02:01-Restricted 20mer Epitope.,Meeuwsen MH, Wouters AK, Hagedoorn RS, Kester MGD, Remst DFG, van der Steen DM, de Ru A, van Veelen PA, Rossjohn J, Gras S, Falkenburg JHF, Heemskerk MHM J Immunol. 2022 Apr 15;208(8):1851-1856. doi: 10.4049/jimmunol.2101208. Epub 2022 , Apr 4. PMID:35379743<ref>PMID:35379743</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7t5m" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[MHC 3D structures|MHC 3D structures]] | |||
*[[MHC I 3D structures|MHC I 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gras S]] | |||
Latest revision as of 11:32, 23 October 2024
Structure of HLA-A*02:01-FLPTPEELGLLGPPRPQVLA complex
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