Pyruvate kinase 3D structures: Difference between revisions

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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
*Pyruvate kinase muscle
**[[1t5a]], [[1zjh]], [[3bjf]], [[3bjt]], [[9hib]] - hPyK M2 muscle - human
**[[3g2g]], [[4qg6]], [[4qg8]], [[4qg9]], [[4qgc]], [[4wj8]], [[4yj5]], [[6b6u]], [[8hgf]] - hPyK M2 muscle (mutant)
**[[3srf]], [[3srh]] – hPyK M1 muscle
**[[6wp3]], [[6wp4]], [[6wp5]], [[6wp6]] – hPyK M2 muscle (mutant)
**[[1pkm]], [[1pyk]] – PyK muscle – cat
**[[1f3w]], [[8f5t]] – rPyK muscle – rabbit
**[[1f3x]], [[7r6y]] - rPyK muscle (mutant)
*Pyruvate kinase muscle binary complexes
**[[4b2d]], [[9hic]] - hPyK M2 muscle + fructose bisphosphate
**[[4rpp]] - hPyK M2 muscle (mutant) + fructose bisphosphate
**[[4fxj]] - hPyK M2 muscle + phenylalanine
**[[6gg3]] - hPyK M2 muscle + alanine
**[[6gg4]] - hPyK M2 muscle + phenylalanine
**[[6gg5]] - hPyK M2 muscle + tryptophan
**[[6gg6]] - hPyK M2 muscle + serine
**[[6nub]] - hPyK M2 muscle (mutant) + serine
**[[6nu1]] - hPyK M2 muscle + cysteine
**[[6nu5]] - hPyK M2 muscle (mutant) + cysteine
**[[6ttf]], [[6tti]], [[6ttq]] - hPyK M2 muscle + inhibitor – Cryo EM
**[[6tth]] - hPyK M2 muscle + threonine – Cryo EM
**[[6v74]], [[6v75]] - hPyK M2 muscle + asparagine
**[[6v76]] - hPyK M2 muscle + valine
**[[8g2e]], [[9iqq]], [[9o3b]] - hPyK M2 muscle + activator
**[[8f5u]] - rPyK muscle + pyruvate
*Pyruvate kinase muscle higher complexes
**[[3me3]] – hPyK M1/M2 muscle + aniline derivative + fructose bisphosphate
**[[4g1n]] - hPyK M1/M2 muscle + pyridazine derivative + oxalate
**[[3h6o]] - hPyK M1/M2 muscle + pyridazine derivative + fructose bisphosphate
**[[3gqy]], [[3gr4]], [[3u2z]] - hPyK M1/M2 muscle + piperazine derivative + fructose bisphosphate
**[[8hmq]], [[8hmr]], [[8hms]], [[8hmu]] - hPyK muscle (mutant) + Pi + fructose bisphosphate
**[[5x0i]] - hPyK M2 muscle (mutant) + serine + fructose bisphosphate
**[[7l21]] - hPyK M2 muscle (mutant) + oxalate + fructose bisphosphate
**[[6jfb]] - hPyK M2 muscle + serine + phosphate
**[[5x1v]], [[5x1w]] - hPyK M2 muscle + activator + fructose bisphosphate
**[[4jpg]] - hPyK M1/M2 muscle + pyrimidine derivative +fructosebisphosphate
**[[3srd]] - hPyK M1/M2 muscle + oxalate + fructose bisphosphate
**[[4fxf]] - hPyK M1/M2 muscle + oxalate + ATP + fructose bisphosphate
**[[3n25]] – rPyK M1/M2 muscle + proline + Mn + pyruvate
**[[2g50]] - rPyK M1/M2 muscle + alanine + Mn + pyruvate
**[[8f6m]] - rPyK muscle + Ala + Mn + ADP
**[[1pkn]] - rPyK muscle + Mn + pyruvate
**[[1aqf]] – rPyK muscle + Mg + phospholactate
**[[1a49]], [[1a5u]] - rPyK muscle + ATP + oxalate
*Pyruvate kinase liver
**[[9vxp]] - hPyK liver – Cryo EM
**[[2vgb]] – hPyK liver
**[[2vgf]], [[2vgg]], [[2vgi]] [[6nn5]], [[6nn7]], [[6nn8]], [[7qdn]] – hPyK liver (mutant)
**[[9w4q]], [[9w7y]], [[9w81]] - hPyK liver + activator – Cryo EM
**[[8tbs]], [[8tbt]], [[8tbu]] - hPyK liver + activator
**[[7fs7]] - hPyK liver + modulator
**[[9wdo]], [[9wdq]], [[9wdr]], [[9edt]] - hPyK liver + drug – Cryo EM
**[[8xfd]] - hPyK liver + activator
**[[9r3h]], [[9r3i]], [[9r3l]], [[9r3m]], [[9r3o]], [[9rdf]], [[9rfq]], [[9rft]] - hPyK liver + fluorescent probe
**[[9wez]] - hPyK liver + fructose bisphosphate – Cryo EM
**[[6nn4]] - hPyK M2 liver (mutant) + fructose bisphosphate
**[[6ech]], [[6eck]] - PyK liver + fructose bisphosphate - rat
**[[5sc8]], [[5sc9]], [[5sca]], [[5scb]], [[5scc]], [[5scd]], [[5sce]], [[5scf]], [[5scg]], [[5sch]], [[5sci]], [[5scj]], [[5sck]], [[5scl]], [[5sdt]], [[7qzu]] - hPyK liver + anthracene derivative + fructose bisphosphate
**[[7frv]], [[7frw]], [[7frx]], [[7fry]], [[7frz]], [[7fs0]], [[7fs1]], [[7fs2]], [[7fs3]], [[7fs4]], [[7fs5]], [[7fs6]], [[7fs8]], [[7fs9]], [[7fsa]], [[7fsb]], [[7fsc]], [[7fsd]] - hPyK liver + modulator + fructose bisphosphate
**[[4ima]], [[4ip7]] - hPyK liver (mutant) + citrate + adenosine + fructose bisphosphate


*Pyruvate kinase
*Pyruvate kinase


**[[3bjf]], [[3bjt]], [[1t5a]], [[1zjh]], [[3srf]], [[3srh]] - hPyK M1/M2 - human<br />
**[[6du6]] – PyK - mosquito
**[[4wj8]], [[4qg6]], [[4qg8]], [[4qg9]], [[4qgc]], [[3g2g]], [[4yj5]], [[6b6u]] - hPyK M1/M2 (mutant)<br />
**[[1pky]], [[4yng]], [[6k0k]] – EcPyK - Eschericia coli
**[[2vgb]] – hPyK LR<br /> 
**[[1e0t]], [[1e0u]], [[8edq]], [[8edr]], [[8eds]], [[8edt]], [[8eq0]], [[8eq1]], [[8eq3]], [[8eu4]] - EcPyK (mutant)
**[[6nn5]], [[6nn7]], [[6nn8]], [[2vgf]], [[2vgg]], [[2vgi]] – hPyK LR (mutant)<br />
**[[3t05]], [[3t0t]] – SaPyK – Staphylococcus aureus
**[[1pkm]], [[1pyk]] – PyK – cat<br />
**[[3qtg]] – PyK – Pyrobaculum aerophilum
**[[1f3w]] – rPyK – rabbit<br />
**[[4krz]] – TcPyK – Trypanosoma cruzei
**[[1f3x]] - rPyK (mutant) <br />
**[[5wrp]] - MtPyK – Mycobacterium tuberculosis
**[[6du6]] – PyK - mosquito<br />
**[[1pkl]], [[3e0w]], [[3hqn]] – LmPyK – Leishmania mexicana
**[[1pky]], [[4yng]], [[6k0k]] – EcPyK - ''Eschericia coli''<br />
**[[3khd]], [[7z4m]] – PfPyK – Plasmodium falciparum
**[[1e0t]], [[1e0u]] - EcPyK (mutant) <br />
**[[7z4q]], [[7z4r]] - PfPyK (mutant)
**[[3t05]], [[3t0t]] – SaPyK – ''Staphylococcus aureus''<br />
**[[3eoe]], [[3gg8]] – PyK – Toxoplasma gondii
**[[3qtg]] – PyK – ''Pyrobaculum aerophilum''<br />
**[[3ma8]], [[4drs]] – CpPyK – Cryptosporidium parvum
**[[4krz]] - TcPyK – ''Trypanosoma cruzei''<br />
**[[2e28]] - PyK (mutant) – Geobacillus stearothermophilus
**[[5wrp]] - MtPyK – ''Mycobacterium tuberculosis''<br />
**[[7oo1]] – PaPyK – Pseudomonas aeruginosa
**[[3hqn]], [[3e0w]], [[1pkl]] – LmPyK – ''Leishmania mexicana''<br />
**[[7ueh]] – PyK – Zymomonas mobilis
**[[3khd]] – PfPyK – ''Plasmodium falciparum''<br />
**[[8ias]] - SpPyK – Streptococcus pneumoniae
**[[3gg8]], [[3eoe]] – PyK – ''Toxoplasma gondii''<br />
**[[8iw2]] - PyK – Entamoeba histolytica
**[[3ma8]], [[4drs]] – PyK – ''Cryptosporidium parvum''<br />
**[[2e28]] - PyK (mutant) – ''Geobacillus stearothermophilus''<br />
**[[7oo1]] – PaPyK – ''Pseudomonas aeruginosa''<br />


*Pyruvate kinase binary complex
*Pyruvate kinase binary complex


**[[4b2d]] - hPyK M1/M2 + fructose bisphosphate<br />
**[[8x4r]] – hPyK + Phe
**[[4rpp]], [[6nn4]] - hPyK M2 (mutant) + fructose bisphosphate<br />
**[[3qv9]] – TcPyK + Ponceau S
**[[4fxj]] - hPyK M1/M2 + phenylalanine<br />
**[[3qv6]] – LmPyK + acid blue 80
**[[6gg3]] - hPyK M2 + alanine<br />
**[[3e0v]] – LmPyK + sulfate
**[[6gg4]] - hPyK M2 + phenylalanine<br />
**[[3hqq]] - LmPyK + fructose bisphosphate
**[[6gg5]] - hPyK M2 + tryptophan<br />
**[[3qv8]] – LmPyK + benzothiazole
**[[6gg6]] - hPyK M2 + serine<br />
**[[3pp7]] – LmPyK + suramin
**[[6nub]] - hPyK M2 (mutant) + serine<br />
**[[3is4]], [[3ktx]] – LmPyK + pyrenetetrasulfonic acid
**[[6nu1]] - hPyK M2 + cysteine<br />
**[[3t07]] – SaPyK + bis-indole alkaloid
**[[6nu5]] - hPyK M2 (mutant) + cysteine<br />
**[[4hyw]] – TbPyK + fructose bisphosphate – Trypanosoma brucei
**[[6ttf]], [[6tti]], [[6ttq]] - hPyK M2 + inhibitor – Cryo EM<br />
**[[6su1]], [[6su2]] – PyK + citrate – Trypanosoma congolense
**[[6tth]] - hPyK M2 + threonine – Cryo EM<br />
**[[5ws8]] - MtPyK + oxalate
**[[6v74]], [[6v75]] - hPyK M2+ asparagine <br />
**[[6p0y]] - CpPyK + ADP
**[[6v76]] - hPyK M2 + valine <br />
**[[8iav]] - SpPyK + fructose bisphosphate
**[[6ech]], [[6eck]] - PyK PKLR + fructose bisphosphate - rat<br />
**[[8iat]] - SpPyK + oxalate
**[[5x1v]], [[5x1w]] - hPyK M2 + inhibitor<br />
**[[8iaw]] - SpPyK + phosphoenolpyruvate
**[[4rpp]] - hPyK M2 (mutant) + fructose bisphosphate<br />**[[3qv9]] – TcPyK + Ponceau S <br />
**[[7z4n]] -PfPyK + pyruvate
**[[3qv6]] – LmPyK + acid blue 80<br />
**[[8rtf]], [[8rvr]] -PyK + antibody – Trypanosoma congolense
**[[3e0v]] – LmPyK + sulfate<br />
**[[3hqq]] - LmPyK + fructose bisphosphate<br />
**[[3qv8]] – LmPyK + benzothiazole<br />
**[[3pp7]] – LmPyK + suramin<br />
**[[3is4]], [[3ktx]] – LmPyK + pyrenetetrasulfonic acid<br />
**[[3t07]] – SaPyK + bis-indole alkaloid<br />
**[[4hyw]] – TbPyK + fructose bisphosphate – ''Trypanosoma brucei''<br />
**[[6su1]], [[6su2]] – PyK + citrate – ''Trypanosoma congolense''<br />
**[[5ws8]] - MtPyK + oxalate<br />
**[[6p0y]] - CpPyK + ADP<br />
 
*Pyruvate kinase higher complex


**[[3me3]] – hPyK M1/M2 + aniline derivative + fructose bisphosphate<br />
*Pyruvate kinase higher complexes
**[[4g1n]] - hPyK M1/M2 + pyridazine derivative + oxalate<br />
**[[3h6o]] - hPyK M1/M2 + pyridazine derivative + fructose bisphosphate<br />
**[[3gqy]], [[3gr4]], [[3u2z]] - hPyK M1/M2 + piperazine derivative + fructose bisphosphate<br />
**[[5x0i]] - hPyK M2 (mutant) + serine + fructose bisphosphate<br />
**[[7l21]] - hPyK M2 (mutant) + oxalate + fructose bisphosphate<br />
**[[6jfb]] - hPyK M2 + serine + phosphate<br />
**[[5x1v]], [[5x1w]] - hPyK M2 + activator + fructose bisphosphate<br />
**[[4jpg]] - hPyK M1/M2 + pyrimidine derivative + fructose bisphosphate<br />
**[[3srd]] - hPyK M1/M2 + oxalate + fructose bisphosphate<br />
**[[4fxf]] - hPyK M1/M2 + oxalate + ATP + fructose bisphosphate<br />
**[[4ima]], [[4ip7]] - hPyK L (mutant) + citrate + adenosine + fructose bisphosphate<br />
**[[3n25]] – rPyK M1/M2 + proline + Mn + pyruvate<br />
**[[2g50]] - rPyK M1/M2 + alanine + Mn + pyruvate<br />
**[[1pkn]] - rPyK + Mn + pyruvate<br />
**[[1aqf]] – rPyK + Mg + phospholactate<br />
**[[1a49]], [[1a5u]] - rPyK + ATP + oxalate<br />
**[[1a3w]] – yPyK + Mn + phosphoglycolic acid + fructose bisphosphate – yeast<br />
**[[1a3x]] - yPyK + Mn + phosphoglycolic acid<br />
**[[4hyv]] – TbPyK + phosphoenolpyruvate + fructose bisphosphate <br />
**[[4kct]] – TbPyK + pyruvate + fructose bisphosphate <br />
**[[4kcu]] – TbPyK + malate + fructose bisphosphate <br />
**[[4kcv]] – TbPyK + oxoglutarate + fructose bisphosphate <br />
**[[4kcw]] – TbPyK + oxalate + fructose bisphosphate <br />
**[[4ks0]] – TcPyK + oxalate + fructose bisphosphate <br />
**[[5ws9]] – MtPyK + oxalate + AMP + ATP <br />
**[[5wsa]] – MtPyK + oxalate + glucose-6-phosphate <br />
**[[5wsb]], [[5wsc]] – MtPyK + oxalate + glucose-6-phosphate + AMP<br />
**[[6ito]] – MtPyK + oxalate + ribose-5-phosphate + AMP<br />
**[[3hqo]] – LmPyK + ATP + oxalate<br />
**[[3hqp]] - LmPyK + ATP + oxalate + fructose bisphosphate<br />
**[[3qv7]] – LmPyK + acid blue 25 + Ponceau S<br />
**[[3srk]] – LmPyK + saccharine + inhibitor<br />
**[[6qxl]] – PaPyK + malonate + glucose-6-phosphate + Mg <br />
**[[6ksh]] – PfPyK + oxalate + ATP <br />


**[[8xfd]] – hPyK + activator + fructose bisphosphate
**[[1a3w]] – yPyK + Mn + phosphoglycolic acid + fructose bisphosphate – yeast
**[[1a3x]] - yPyK + Mn + phosphoglycolic acid
**[[4hyv]] – TbPyK + phosphoenolpyruvate + fructose bisphosphate
**[[4kct]] – TbPyK + pyruvate + fructose bisphosphate
**[[4kcu]] – TbPyK + malate + fructose bisphosphate
**[[4kcv]] – TbPyK + oxoglutarate + fructose bisphosphate
**[[4kcw]] – TbPyK + oxalate + fructose bisphosphate
**[[4ks0]] – TcPyK + oxalate + fructose bisphosphate
**[[5ws9]] – MtPyK + oxalate + AMP + ATP
**[[5wsa]] – MtPyK + oxalate + glucose-6-phosphate
**[[5wsb]], [[5wsc]] – MtPyK + oxalate + glucose-6-phosphate + AMP
**[[6ito]] – MtPyK + oxalate + ribose-5-phosphate + AMP
**[[3hqo]] – LmPyK + ATP + oxalate
**[[3hqp]] - LmPyK + ATP + oxalate + fructose bisphosphate
**[[3qv7]] – LmPyK + acid blue 25 + Ponceau S
**[[3srk]] – LmPyK + saccharine + inhibitor
**[[6qxl]] – PaPyK + malonate + glucose-6-phosphate + Mg
**[[6ksh]] – PfPyK + oxalate + ATP
**[[8iax]] - SpPyK + fructose bisphosphate + phosphoenolpyruvate
**[[8iau]] - SpPyK + fructose bisphosphate + oxalate
**[[8xw6]], [[8xw7]], [[8xw8]], [[8xw9]], [[8zly]] - SpPyK + fructose bisphosphate + oxalate + nucleotide
}}
}}


[[Category: Topic Page]]
[[Category: Topic Page]]

Latest revision as of 13:43, 14 September 2026

3D structures of pyruvate kinase

Updated on 14-September-2026

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Openfox, Jaime Prilusky

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