7wwo: Difference between revisions
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New page: '''Unreleased structure''' The entry 7wwo is ON HOLD Authors: Yuvaraj, I., Sekar, K. Description: Dimer form of hypothetical protein TTHA1873 from Thermus thermophilus [[Category: Unre... |
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The | ==Dimer form of hypothetical protein TTHA1873 from Thermus thermophilus== | ||
<StructureSection load='7wwo' size='340' side='right'caption='[[7wwo]], [[Resolution|resolution]] 2.17Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7wwo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7WWO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7WWO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.17Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7wwo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7wwo OCA], [https://pdbe.org/7wwo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7wwo RCSB], [https://www.ebi.ac.uk/pdbsum/7wwo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7wwo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q5SH57_THET8 Q5SH57_THET8] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The crystal structure of an uncharacterized hypothetical protein, TTHA1873 from Thermus thermophilus, has been determined by X-ray crystallography to a resolution of 1.78 A using the single-wavelength anomalous dispersion method. The protein crystallized as a dimer in two space groups: P43212 and P6122. Structural analysis of the hypothetical protein revealed that the overall fold of TTHA1873 has a beta-sandwich jelly-roll topology with nine beta-strands. TTHA1873 is a dimeric metal-binding protein that binds to two Ca(2+) ions per chain, with one on the surface and the other stabilizing the dimeric interface of the two chains. A structural homology search indicates that the protein has moderate structural similarity to one domain of cell-surface proteins or agglutinin receptor proteins. Red blood cells showed visible agglutination at high concentrations of the hypothetical protein. | |||
Structure of the hypothetical protein TTHA1873 from Thermus thermophilus.,Yuvaraj I, Chaudhary SK, Jeyakanthan J, Sekar K Acta Crystallogr F Struct Biol Commun. 2022 Sep 1;78(Pt 9):338-346. doi:, 10.1107/S2053230X22008457. Epub 2022 Aug 30. PMID:36048084<ref>PMID:36048084</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 7wwo" style="background-color:#fffaf0;"></div> | ||
[[Category: Sekar | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Thermus thermophilus HB8]] | |||
[[Category: Sekar K]] | |||
[[Category: Yuvaraj I]] | |||
Latest revision as of 17:45, 29 November 2023
Dimer form of hypothetical protein TTHA1873 from Thermus thermophilus
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