7z05: Difference between revisions
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==White Bream virus N7-Methyltransferase== | |||
<StructureSection load='7z05' size='340' side='right'caption='[[7z05]], [[Resolution|resolution]] 2.33Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7z05]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/White_bream_virus White bream virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Z05 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Z05 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7z05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7z05 OCA], [https://pdbe.org/7z05 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7z05 RCSB], [https://www.ebi.ac.uk/pdbsum/7z05 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7z05 ProSAT]</span></td></tr> | ||
[[Category: Canard | </table> | ||
[[Category: Gauffre | == Function == | ||
[[Category: Shannon | [https://www.uniprot.org/uniprot/R1AB_WBV24 R1AB_WBV24] Catalyzes the RNA N7-guanylyltransferase reaction to methylate the core cap structure GpppN-RNA into the type-0 cap (m)GpppN-RNA.<ref>PMID:36265859</ref> The 3C-like serine proteinase is responsible for the majority of cleavages.<ref>PMID:21068254</ref> The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. The exoribonuclease acts on ssRNA in a 3' to 5' direction (PubMed:30058998). Most active on dsRNA substrates containing one or two non-paired 3'-terminal nucleotides, thereby probably increasing the fidelity of the viral RNA-dependent RNA polymerase by excising RNA 3'-end mismatches during viral RNA replication (PubMed:30058998).<ref>PMID:30058998</ref> NendoU is a Mn(2+)-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond. Catalyzes the RNA 2'-O-ribose methyltransferase reaction to methylate the type-0 cap into the type-1 cap (m)GpppN(m)-RNA.[UniProtKB:P0C6X7] | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: White bream virus]] | |||
[[Category: Canard B]] | |||
[[Category: Ferron F]] | |||
[[Category: Gauffre P]] | |||
[[Category: Shannon A]] | |||
Latest revision as of 08:48, 11 December 2025
White Bream virus N7-Methyltransferase
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