7x2u: Difference between revisions
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The entry | ==Structure of a human NHE3-CHP1 complex in the autoinhibited state== | ||
<StructureSection load='7x2u' size='340' side='right'caption='[[7x2u]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7x2u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7X2U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7X2U FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=85R:[(2~{R})-2-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{S},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propyl]+hexadecanoate'>85R</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7x2u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7x2u OCA], [https://pdbe.org/7x2u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7x2u RCSB], [https://www.ebi.ac.uk/pdbsum/7x2u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7x2u ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/SL9A3_HUMAN SL9A3_HUMAN] Congenital sodium diarrhea;Cystic fibrosis. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SL9A3_HUMAN SL9A3_HUMAN] Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773).[UniProtKB:G3X939]<ref>PMID:18829453</ref> <ref>PMID:24622516</ref> <ref>PMID:26358773</ref> <ref>PMID:35613257</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dong Y]] | |||
[[Category: Gao Y]] | |||
[[Category: Li H]] | |||
[[Category: Zhang XC]] | |||
[[Category: Zhao Y]] | |||
Latest revision as of 06:26, 3 July 2025
Structure of a human NHE3-CHP1 complex in the autoinhibited state
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