7r7q: Difference between revisions
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==Immature HIV-1 CACTD-SP1 lattice with Inositol hexakisphosphate (IP6)== | |||
<StructureSection load='7r7q' size='340' side='right'caption='[[7r7q]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7r7q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R7Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R7Q FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solid-state NMR, models</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r7q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r7q OCA], [https://pdbe.org/7r7q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r7q RCSB], [https://www.ebi.ac.uk/pdbsum/7r7q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r7q ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GAG_HV1N5 GAG_HV1N5] Matrix protein p17 targets Gag and Gag-Pol polyproteins to the plasma membrane via a multipartite membrane binding signal, that includes its myristoylated N-terminus. Also mediates nuclear localization of the preintegration complex. Implicated in the release from host cell mediated by Vpu. Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers. p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1 (By similarity). | |||
==See Also== | |||
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Human immunodeficiency virus 1]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Ablan S]] | ||
[[Category: | [[Category: Freed EO]] | ||
[[Category: Kleinpeter | [[Category: Ganser-Pornillos BK]] | ||
[[Category: | [[Category: Gronenborn AM]] | ||
[[Category: | [[Category: Kleinpeter A]] | ||
[[Category: | [[Category: Meshkin H]] | ||
[[Category: | [[Category: Perilla JR]] | ||
[[Category: | [[Category: Polenova T]] | ||
[[Category: Russell | [[Category: Pornillos O]] | ||
[[Category: | [[Category: Quinn CM]] | ||
[[Category: | [[Category: Russell RW]] | ||
[[Category: | [[Category: Sarkar S]] | ||
[[Category: Zadorozhnyi R]] | |||
[[Category: Zadrozny KK]] | |||
Latest revision as of 08:44, 29 April 2026
Immature HIV-1 CACTD-SP1 lattice with Inositol hexakisphosphate (IP6)
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