7y1f: Difference between revisions
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The entry | ==Cryo-EM structure of human k-opioid receptor-Gi complex== | ||
<StructureSection load='7y1f' size='340' side='right'caption='[[7y1f]], [[Resolution|resolution]] 3.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7y1f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y1F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y1f OCA], [https://pdbe.org/7y1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y1f RCSB], [https://www.ebi.ac.uk/pdbsum/7y1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y1f ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN] Spinocerebellar ataxia type 23. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDYN_HUMAN PDYN_HUMAN] Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect. | |||
==See Also== | |||
*[[Opioid receptor|Opioid receptor]] | |||
*[[Transducin 3D structures|Transducin 3D structures]] | |||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Chen BO]] | |||
[[Category: Xu FE]] | |||
Latest revision as of 11:45, 23 October 2024
Cryo-EM structure of human k-opioid receptor-Gi complex
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