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[[Image:1hq8.gif|left|200px]]
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{{STRUCTURE_1hq8|  PDB=1hq8  |  SCENE=  }}
'''CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A'''


==CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A==
<StructureSection load='1hq8' size='340' side='right'caption='[[1hq8]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1hq8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HQ8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hq8 OCA], [https://pdbe.org/1hq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hq8 RCSB], [https://www.ebi.ac.uk/pdbsum/1hq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hq8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NKG2D_MOUSE NKG2D_MOUSE] Receptor for RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. Involved in the immune surveillance exerted by T and B lymphocytes.<ref>PMID:12370332</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hq/1hq8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1hq8 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells,T cells and activated macrophages.The natural ligands for murine NKG2D are distant major histocompatibility complex homologs, retinoic acid early transcript (Rae1) and H-60 minor histocompatibility antigen. The crystal structure of the extracellular region of murine NKG2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer receptors, as well as their surface topography and electrostatic properties.The NKG2D structure provides the first structural insights into the role and ligand specificity of this stimulatory receptor in the innate and adaptive immune system.


==Overview==
Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.,Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA Nat Immunol. 2001 Mar;2(3):248-54. PMID:11224525<ref>PMID:11224525</ref>
NKG2D, a homodimeric lectin-like receptor, is a unique stimulatory molecule that is found on natural killer cells,T cells and activated macrophages.The natural ligands for murine NKG2D are distant major histocompatibility complex homologs, retinoic acid early transcript (Rae1) and H-60 minor histocompatibility antigen. The crystal structure of the extracellular region of murine NKG2D reveals close homology with other C-type lectin receptors such as CD94, Ly49A, rat MBP-A and CD69. However, the precise mode of dimeric assembly varies among these natural killer receptors, as well as their surface topography and electrostatic properties.The NKG2D structure provides the first structural insights into the role and ligand specificity of this stimulatory receptor in the innate and adaptive immune system.


==About this Structure==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
1HQ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HQ8 OCA].
</div>
<div class="pdbe-citations 1hq8" style="background-color:#fffaf0;"></div>


==Reference==
==See Also==
Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A., Wolan DW, Teyton L, Rudolph MG, Villmow B, Bauer S, Busch DH, Wilson IA, Nat Immunol. 2001 Mar;2(3):248-54. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11224525 11224525]
*[[NK cell receptor|NK cell receptor]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Bauer S]]
[[Category: Bauer, S.]]
[[Category: Busch DH]]
[[Category: Busch, D H.]]
[[Category: Rudolph MG]]
[[Category: Rudolph, M G.]]
[[Category: Teyton L]]
[[Category: Teyton, L.]]
[[Category: Villmow B]]
[[Category: Villmow, B.]]
[[Category: Wilson IA]]
[[Category: Wilson, I A.]]
[[Category: Wolan DW]]
[[Category: Wolan, D W.]]
[[Category: Cis-proline]]
[[Category: Homodimer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:06:56 2008''

Latest revision as of 04:35, 17 October 2024

CRYSTAL STRUCTURE OF THE MURINE NK CELL-ACTIVATING RECEPTOR NKG2D AT 1.95 A

1hq8, resolution 1.95Å

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