7ylf: Difference between revisions
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The | ==Crystal structure of the chicken Toll-like receptor 15 TIR domain (2-mercaptoethanol adduct)== | ||
<StructureSection load='7ylf' size='340' side='right'caption='[[7ylf]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7ylf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YLF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ylf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ylf OCA], [https://pdbe.org/7ylf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ylf RCSB], [https://www.ebi.ac.uk/pdbsum/7ylf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ylf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/E5L3Q3_CHICK E5L3Q3_CHICK] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Toll-like receptors (TLRs) activate innate immunity in response to pathogen-associated molecular patterns (PAMPs). The ectodomain of a TLR directly senses a PAMP and the intracellular TIR domain dimerizes to initiate a signaling cascade. The TIR domains of TLR6 and TLR10, which belong to the TLR1 subfamily, have been structurally characterized in a dimer, whereas those of other subfamilies, including TLR15, have not been explored at the structural or molecular level. TLR15 is a TLR unique to birds and reptiles that responds to virulence-associated fungal and bacterial proteases. To reveal how the TLR15 TIR domain (TLR15(TIR)) triggers signaling, the crystal structure of TLR15(TIR) was determined in a dimeric form and a mutational study was performed. TLR15(TIR) forms a one-domain structure in which a five-stranded beta-sheet is decorated by alpha-helices, as shown for TLR1 subfamily members. TLR15(TIR) exhibits substantial structural differences from other TLRs at the BB and DD loops and alphaC2 helix that are involved in dimerization. As a result, TLR15(TIR) is likely to form a dimeric structure that is unique in its intersubunit orientation and the contribution of each dimerizing region. Further comparative analysis of TIR structures and sequences provides insights into the recruitment of a signaling adaptor protein by TLR15(TIR). | |||
Structural analysis of the Toll-like receptor 15 TIR domain.,Ko KY, Song WS, Park J, Lee GS, Yoon SI IUCrJ. 2023 May 1;10(Pt 3):352-362. doi: 10.1107/S2052252523002956. PMID:37079400<ref>PMID:37079400</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
<div class="pdbe-citations 7ylf" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gallus gallus]] | |||
[[Category: Large Structures]] | |||
[[Category: Ko KY]] | |||
[[Category: Song WS]] | |||
[[Category: Yoon SI]] | |||
Latest revision as of 11:47, 23 October 2024
Crystal structure of the chicken Toll-like receptor 15 TIR domain (2-mercaptoethanol adduct)
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