Flocculation protein: Difference between revisions

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== Function ==

'''Flocculation protein''' or''' flocculin''' (FLO) are yeast adhesion protein family involved in cell-cell adhesion via lectin-carbohydrate interaction<ref>PMID:20640875</ref>. FLO1, FLO5, FLO9 and FLO10 have similar sequence and cause formation of cellular clumps (flocs) while FLO11 has unrelated sequence and is required for diploid formation and haploid invasive growth.

'''Flocculation protein''' or''' flocculin''' (FLO) are yeast adhesion protein family involved in cell-cell adhesion via lectin-carbohydrate interaction<ref>PMID:20640875</ref>. '''FLO1, FLO5, FLO9 and FLO10''' have similar sequence and cause formation of cellular clumps (flocs) while '''FLO11''' has unrelated sequence and is required for diploid formation and haploid invasive growth. Flocculins confer calcium-dependent cell-cell adhesion, formation of cellular flocs and protection against environmental stress.

== ~~Disease~~ ==

== Relevance ==

~~== Relevance ==~~

The process of flocculation has an important role in the production of beer and wine<ref>PMID:12698276</ref>.

== Structural highlights ==

~~This~~ is a ~~sample scene created~~ with ~~SAT to~~ <~~scene name="/12/3456/Sample/1"~~>~~color~~</~~scene~~> ~~by Group, and another to make~~ <scene name="/12/~~3456~~/~~Sample/2"~~>~~a transparent representation~~</scene> of ~~the~~ protein~~. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.~~

The N-terminal domain of FLO is similar to the lectin-like domain of [[Adhesin]]. The Ca+2 ion binds to two carbohydrate-binding groups: a D''cis''D motif - 2 Asp residues connected with a ''cis'' bond and another β strand residues. The Ca+2 ion interacts with α-mannose which is an antiflocculant in vivo<ref>PMID:21149680</ref>. <scene name='91/919029/Cv/7'>α-mannose binding site</scene>.

==3D structures of flocculation protein==

[[Flocculation protein 3D structures]]

</StructureSection>

== References ==

[[Category:Topic Page]]

Flocculation protein: Difference between revisions

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-<StructureSection load='4ahw' size='340' side='right' caption='Caption for this structure' scene=''>
+<StructureSection load='2xjp' size='340' side='right' caption='FLO5 N-terminal domain complex with α-mannose, β-mannose, Ca+2 (large green), Cl- (small green) and K+ (purple) ions (PDB ID [[2xjp]])' scene='91/919029/Cv/1'>
 == Function ==
-'''Flocculation protein''' or''' flocculin''' (FLO) are yeast adhesion protein family involved in cell-cell adhesion via lectin-carbohydrate interaction<ref>PMID:20640875</ref>.  FLO1, FLO5, FLO9 and FLO10 have similar sequence and cause formation of cellular clumps (flocs) while FLO11 has unrelated sequence and is required for diploid formation and haploid invasive growth.
+'''Flocculation protein''' or''' flocculin''' (FLO) are yeast adhesion protein family involved in cell-cell adhesion via lectin-carbohydrate interaction<ref>PMID:20640875</ref>. '''FLO1, FLO5, FLO9 and FLO10''' have similar sequence and cause formation of cellular clumps (flocs) while '''FLO11''' has unrelated sequence and is required for diploid formation and haploid invasive growth. Flocculins confer calcium-dependent cell-cell adhesion, formation of cellular flocs and protection against environmental stress.
-== Disease ==
+== Relevance ==
-== Relevance ==
+The process of flocculation has an important role in the production of beer and wine<ref>PMID:12698276</ref>.
 == Structural highlights ==
-This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
+The N-terminal domain of FLO is similar to the lectin-like domain of [[Adhesin]]. The Ca+2 ion binds to two carbohydrate-binding groups: a D''cis''D motif - 2 Asp residues connected with a ''cis'' bond and another β strand residues. The Ca+2 ion interacts with α-mannose which is an antiflocculant in vivo<ref>PMID:21149680</ref>. <scene name='91/919029/Cv/7'>α-mannose binding site</scene>.
+==3D structures of flocculation protein==
+[[Flocculation protein 3D structures]]
 </StructureSection>
 == References ==
 <references/>
+[[Category:Topic Page]]