8h33: Difference between revisions
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==Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex== | |||
<StructureSection load='8h33' size='340' side='right'caption='[[8h33]], [[Resolution|resolution]] 7.86Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8h33]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H33 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H33 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.86Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h33 OCA], [https://pdbe.org/8h33 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h33 RCSB], [https://www.ebi.ac.uk/pdbsum/8h33 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h33 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KBTB2_HUMAN KBTB2_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation.<ref>PMID:27708159</ref> | |||
==See Also== | |||
*[[Ring box protein 3D structures|Ring box protein 3D structures]] | |||
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]] | |||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: Mao | </StructureSection> | ||
[[Category: Sun | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | |||
[[Category: Chen Z]] | |||
[[Category: Hu Y]] | |||
[[Category: Mao Q]] | |||
[[Category: Sun L]] | |||
Latest revision as of 09:32, 20 March 2024
Cryo-EM Structure of the KBTBD2-Cul3-Rbx1 tetrameric complex
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