8i4n: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
New page: '''Unreleased structure''' The entry 8i4n is ON HOLD Authors: Yu, H., Kim, K.-J. Description: Crystal strcuture of 6-phosphogluconate dehydrogenase from Corynebacterium glutamicum [[Ca...
 
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 8i4n is ON HOLD
==Crystal strcuture of 6-phosphogluconate dehydrogenase from Corynebacterium glutamicum==
<StructureSection load='8i4n' size='340' side='right'caption='[[8i4n]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8i4n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum_ATCC_13032 Corynebacterium glutamicum ATCC 13032]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8I4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8I4N FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8i4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8i4n OCA], [https://pdbe.org/8i4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8i4n RCSB], [https://www.ebi.ac.uk/pdbsum/8i4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8i4n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8NQI2_CORGL Q8NQI2_CORGL] Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.[PIRNR:PIRNR000109]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Corynebacterium glutamicum (C. glutamicum) has been considered a very important and meaningful industrial microorganism for the production of amino acids worldwide. To produce amino acids, cells require nicotinamide adenine dinucleotide phosphate (NADPH), which is a biological reducing agent. The pentose phosphate pathway (PPP) can supply NADPH in cells via the 6-phosphogluconate dehydrogenase (6PGD) enzyme, which is an oxidoreductase that converts 6-phosphogluconate (6PG) to ribulose 5-phosphate (Ru5P), to produce NADPH. In this study, we identified the crystal structure of 6PGD_apo and 6PGD_NADP from C. glutamicum ATCC 13032 (Cg6PGD) and reported our biological research based on this structure. We identified the substrate binding site and co-factor binding site of Cg6PGD, which are crucial for understanding this enzyme. Based on the findings of our research, Cg6PGD is expected to be used as a NADPH resource in the food industry and as a drug target in the pharmaceutical industry.


Authors: Yu, H., Kim, K.-J.
Crystal Structures of 6-Phosphogluconate Dehydrogenase from Corynebacterium glutamicum.,Yu H, Hong J, Seok J, Seu YB, Kim IK, Kim KJ J Microbiol Biotechnol. 2023 Oct 28;33(10):1361-1369. doi: , 10.4014/jmb.2305.05002. Epub 2023 Jun 27. PMID:37417004<ref>PMID:37417004</ref>


Description: Crystal strcuture of 6-phosphogluconate dehydrogenase from Corynebacterium glutamicum
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Yu, H]]
<div class="pdbe-citations 8i4n" style="background-color:#fffaf0;"></div>
[[Category: Kim, K.-J]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Corynebacterium glutamicum ATCC 13032]]
[[Category: Large Structures]]
[[Category: Kim K-J]]
[[Category: Yu H]]
Retrieved from "https://proteopedia.org/8i4n"