8fwl: Difference between revisions
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==Crystal structure of Australian bat lyssavirus nucleoprotein in complex with phosphoprotein chaperone== | |||
<StructureSection load='8fwl' size='340' side='right'caption='[[8fwl]], [[Resolution|resolution]] 2.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8fwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lyssavirus_australis Lyssavirus australis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FWL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fwl OCA], [https://pdbe.org/8fwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fwl RCSB], [https://www.ebi.ac.uk/pdbsum/8fwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fwl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q9YZ24_9RHAB Q9YZ24_9RHAB] [https://www.uniprot.org/uniprot/A0A7M4C440_9RHAB A0A7M4C440_9RHAB] Non catalytic polymerase cofactor and regulatory protein that plays a role in viral transcription and replication. Stabilizes the RNA polymerase L to the N-RNA template and binds the soluble protein N, preventing it from encapsidating non-genomic RNA. Also inhibits host IFN-alpha and IFN-beta signaling by binding and retaining phosphorylated STAT1 in the cytoplasm or by inhibiting the DNA binding of STAT1 in the nucleus.[RuleBase:RU004918] | |||
==See Also== | |||
*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Lyssavirus australis]] | ||
[[Category: | [[Category: Donnelly CM]] | ||
[[Category: Forwood JK]] | |||
[[Category: Stewart M]] | |||
Latest revision as of 09:31, 20 March 2024
Crystal structure of Australian bat lyssavirus nucleoprotein in complex with phosphoprotein chaperone
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