8jaq: Difference between revisions
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The | ==Structure of CRL2APPBP2 bound with RxxGP degron (tetramer)== | ||
<StructureSection load='8jaq' size='340' side='right'caption='[[8jaq]], [[Resolution|resolution]] 3.26Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8jaq]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JAQ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.26Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jaq OCA], [https://pdbe.org/8jaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jaq RCSB], [https://www.ebi.ac.uk/pdbsum/8jaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jaq ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CUL2_HUMAN CUL2_HUMAN] Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). | |||
==See Also== | |||
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Xu C]] | |||
[[Category: Zhang K]] | |||
[[Category: Zhao S]] | |||
Latest revision as of 06:13, 23 July 2025
Structure of CRL2APPBP2 bound with RxxGP degron (tetramer)
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