Hydroxysteroid dehydrogenase 3D structures: Difference between revisions

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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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*3-α HSD or AKR1C2
*3-α HSD or AKR1C2
 
* '''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
'''For 3-α HSD type 2 see''' [[Prostaglandin F synthase]]
 
**[[1ral]] – rHSD – rat<BR />
**[[1ral]] – rHSD – rat<BR />
**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />
**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR />
**[[4is2]] – CsHSD – ''Clostridium scindens''<br />
**[[4is2]] – CsHSD – ''Clostridium scindens''<br />
**[[7p36]] - LkHSD – ''Lactobacillus kefiri<''br />
**[[7p36]], [[8kc6]] - LkHSD – ''Lactobacillus kefiri''<br />
 
**[[8kcn]] - LkHSD (mutant)<br />
*''3-α HSD binary complex''
*''3-α HSD binary complex''
**[[2fvl]], [[2hdj]] - hHSD + NADP - human<BR />
**[[2fvl]], [[2hdj]] - hHSD + NADP - human<BR />
**[[1lwi]] – rHSD + NADP<BR />
**[[1lwi]] – rHSD + NADP<BR />
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**[[4is3]] - CsHSD + NAD<br />
**[[4is3]] - CsHSD + NAD<br />
**[[7ejh]], [[7eji]], [[7ejj]], [[7vdo]], [[7vet]] - LkHSD (mutant`) + NADP <br />
**[[7ejh]], [[7eji]], [[7ejj]], [[7vdo]], [[7vet]] - LkHSD (mutant`) + NADP <br />
*''3-α HSD ternary complex''
*''3-α HSD ternary complex''
**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP <br />
**[[4jq1]], [[4jq2]], [[4jq3]], [[4jq4]], [[4jqa]], [[4jtq]], [[4jtr]] - hHSD + NSAID drug + NADP <br />
**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
**[[1afs]] - rHSD + hydroxysteroid + NADP<BR />
*3-α HSD type 3
*3-α HSD type 3
**[[2hdj]] - hHSD + NADP<br />
**[[2hdj]] - hHSD + NADP<br />
**[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP <br />
**[[1ihi]], [[1j96]] - hHSD + hydroxysteroid + NADP <br />
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**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />
**[[4l1x]] - hHSD (mutant) + progesterone + NADP<br />
**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br />
**[[4xo6]], [[4xo7]] – hHSD + NADP + epiandrosterone derivative<br />
*7-α HSD  
*7-α HSD  
 
**[[3gaf]] - BmHSD – ''Brucella melitensis''<BR />
**[[3gaf]] - HSD – ''Brucella melitensis''<BR />
**[[8hax]], [[8hde]], [[8hdi]], [[8hdn]], [[8hs6]], [[8hs9]] - BmHSD (mutant)<BR />
**[[8hs4]], [[8hs5]], [[8hsa]] - BmHSD (mutant) + NAD<BR />
**[[7eny]] – EcHSD – ''Escherichia coli''<br />
**[[7eny]] – EcHSD – ''Escherichia coli''<br />
**[[1ahh]] – EcHSD + NAD <BR />
**[[1ahh]] – EcHSD + NAD <BR />
**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD<br />
**[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD<br />
**[[5epo]] – HSD + NADP – ''Clostridium sardiniese''<br />
**[[5epo]] – HSD + NADP – ''Clostridium sardiniese''<br />
*7-beta HSD   
*7-beta HSD   
**[[5fyd]] – CaHSD – ''Collinsella aerofaciens<''br />
**[[5fyd]] – CaHSD – ''Collinsella aerofaciens<''br />
**[[5gt9]] – CaHSD + NADP<br />
**[[5gt9]] – CaHSD + NADP<br />
*20-α HSD or AKR1C1  
*20-α HSD or AKR1C1  
 
**[[6a7a]], [[8jp2]] – hHSD + NADP + inhibitor<br />
**[[6a7a]] – hHSD + NADP + inhibitor<br />
**[[1q5m]] - raHSD + NADP – rabbit
**[[1q5m]] - raHSD + NADP – rabbit
*''20-α HSD  ternary complex''
*''20-α HSD  ternary complex''
**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
**[[1mrq]] – hHSD + hydroxysteroid + NADP<BR />
**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br />
**[[4yvp]] – hHSD + NADP + sulfonylurea derivative<br />
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**[[6ijx]] – hHSD + NADP + meclofenamic acid<br />
**[[6ijx]] – hHSD + NADP + meclofenamic acid<br />
**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />
**[[1q13]] - raHSD + hydroxysteroid + NADP<BR />
*20-beta HSD   
*20-beta HSD   
**[[6m9u]] – BaHSD – ''Bifidobacterium adolescentis''<br />
**[[6m9u]] – BaHSD – ''Bifidobacterium adolescentis''<br />
**[[6ow4]] – BaHSD + NADP <br />
**[[6ow4]] – BaHSD + NADP <br />
*11-β HSD or corticosteroid  11-β-dehydrogenase 1
*11-β HSD or corticosteroid  11-β-dehydrogenase 1
**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
**[[1xu7]], [[1xu9]] - hHSD (mutant) + NADP<BR />
**[[2pd6]] - hHSD + NAD<BR />
**[[2pd6]] - hHSD + NAD<BR />
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**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
**[[1xse]] - gpHSD catalytic domain + NADP – guinea pig<BR />
**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />
**[[3dwf]], [[3lz6]] - gpHSD catalytic domain (mutant) + NADP<BR />
*''11-β HSD  ternary complex''
*''11-β HSD  ternary complex''
**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR />
**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]], [[4yyz]]  - hHSD 1 + inhibitor + NADP<BR />
**[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]], [[4yyz]]  - hHSD 1 + inhibitor + NADP<BR />
**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3frj]], [[3hfg]], [[3fco]], [[3h6k]], [[3oq1]], [[3pdj]], [[3tfq]], [[3qqp]], [[4c7j]], [[4c7k]], [[4p38]], [[5pgu]], [[5pgv]], [[5pgw]], [[5pgx]], [[5pgy]], [[5pgz]], [[5pii]], [[5pij]], [[5qii]] - hHSD 1 (mutant) + inhibitor + NADP<BR />
**[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3fco]], [[3frj]], [[3h6k]], [[3hfg]], [[3oq1]], [[3pdj]], [[3qqp]], [[3tfq]], [[4c7j]], [[4c7k]], [[4p38]], [[5pgu]], [[5pgv]], [[5pgw]], [[5pgx]], [[5pgy]], [[5pgz]], [[5pii]], [[5pij]], [[5qii]] - hHSD 1 (mutant) + inhibitor + NADP<BR />
**[[6nj7]] - hHSD 1 + colleic acid + NAP<br />
**[[6nj7]] - hHSD 1 + colleic acid + NAP<br />
**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />
**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR />
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**[[4k26]], [[5qij]] - mHSD 1 + inhibitor + NADP<br />
**[[4k26]], [[5qij]] - mHSD 1 + inhibitor + NADP<br />
**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />
**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br />
*17-α HSD or AKR1C21
*17-α HSD or AKR1C21
**[[2he8]] – mHSD - mouse <br />
**[[2he8]] – mHSD - mouse <br />
**[[3fjn]] - mHSD (mutant) <br />
**[[3fjn]] - mHSD (mutant) <br />
**[[2p5n]], [[2he5]], [[2hej]] - mHSD  + NADP <br />
**[[2he5]], [[2hej]], [[2p5n]] - mHSD  + NADP <br />
**[[2ipf]] - mHSD + hydroxysteroid + NADP <br />
**[[2ipf]] - mHSD + hydroxysteroid + NADP <br />
**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />
**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br />
**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />
**[[3cv6]] - mHSD (mutant) + inhibitor + NADP<br />
*17-β HSD or estradiol 11-β-dehydrogenase 1
*17-β HSD or estradiol 11-β-dehydrogenase 1
 
* '''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]
'''For 17-β HSD type 5 or AKR1C3 see''' [[Prostaglandin F synthase]]
 
**[[1bhs]] – hHSD 1 <BR />
**[[1bhs]] – hHSD 1 <BR />
**[[1s9c]] - hHSD 4 (mutant) <BR />
**[[1s9c]] - hHSD 4 (mutant) <BR />
**[[8g9v]] – hHSD 13 <BR />
**[[5ics]] – hHSD 14 <BR />
**[[5ics]] – hHSD 14 <BR />
**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR />
**[[3itd]] - ClHSD (mutant)
**[[3itd]] - ClHSD (mutant)
*''17-β HSD binary complex''
*''17-β HSD binary complex''
 
**[[1fds]], [[1iol]], [[1jtv]], [[1yb1]], [[3dhe]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br />
**[[1jtv]], [[1yb1]], [[3dhe]], [[1fds]], [[1iol]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br />
**[[1dht]], [[1fdw]] - hHSD (mutant) + hydroxysteroid<BR />
**[[1fdw]], [[1dht]] - hHSD (mutant) + hydroxysteroid<BR />
**[[6mnc]] – hHSD 1 + estrone<br />
**[[6mnc]] – hHSD 1 + estrone<br />
**[[1fdv]] - hHSD 1 (mutant) + NAD<BR />
**[[1fdv]] - hHSD 1 (mutant) + NAD<BR />
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**[[1zbq]] - hHSD 4 + NAD<BR />
**[[1zbq]] - hHSD 4 + NAD<BR />
**[[2o23]] – hHSD 10 + NAD<br />
**[[2o23]] – hHSD 10 + NAD<br />
**[[5l7t]], [[5l7w]], [[5l7y]], [[5icm]], [[5en4]] - hHSD 14 + inhibitor<br />
**[[5en4]], [[5icm]], [[5l7t]], [[5l7w]], [[5l7y]] - hHSD 14 + inhibitor<br />
**[[6h0m]], [[6hno]], [[5js6]], [[5jsf]] - hHSD 14 (mutant) + NAD<br />
**[[5js6]], [[5jsf]], [[6h0m]], [[6hno]] - hHSD 14 (mutant) + NAD<br />
**[[8g93]] - HSD 13 (mutant) + NAD - dog<BR />
**[[3qwf]] - ClHSD + NADP<BR />
**[[3qwf]] - ClHSD + NADP<BR />
**[[4fj0]], [[4fj1]], [[4fj2]], [[4fiz]] – ClHSD + dehydroxy flavonoid inhibitor<br />
**[[4fiz]], [[4fj0]], [[4fj1]], [[4fj2]] – ClHSD + dehydroxy flavonoid inhibitor<br />
 
*''17-β HSD ternary complex''
*''17-β HSD ternary complex''
 
**[[1fdt]], [[1qyw]], [[1qyx]] - hHSD 1 + hydroxysteroid + NADP<BR />
**[[1qyw]], [[1qyx]], [[1fdt]] - hHSD 1 + hydroxysteroid + NADP<BR />
**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />
**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR />
**[[3hb5]], [[6cge]] - hHSD 1 + inhibitor + NADP<BR />
**[[3hb5]], [[6cge]] - hHSD 1 + inhibitor + NADP<BR />
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**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br />
**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br />
**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]], [[6qck]] - hHSD 14 + inhibitor + NAD<br />
**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]], [[6qck]] - hHSD 14 + inhibitor + NAD<br />
**[[6ffb]], [[6g4l]], [[6gtu]], [[5o7c]], [[6gbt]], [[6gtb]], [[6zde]], [[6zdi]], [[6zr6]], [[6zra]], [[6zt2]] - hHSD 14 (mutant) + inhibitor + NAD<br />
**[[5o7c]], [[6ffb]], [[6g4l]], [[6gbt]], [[6gtb]], [[6gtu]], [[6zde]], [[6zdi]], [[6zr6]], [[6zra]], [[6zt2]] - hHSD 14 (mutant) + inhibitor + NAD<br />
**[[6emm]] - hHSD 14 (mutant) + salicilate + NAD<br />
**[[6emm]] - hHSD 14 (mutant) + salicilate + NAD<br />
**[[5hs6]] - hHSD 14 + NAD + estrone<br />
**[[5hs6]] - hHSD 14 + NAD + estrone<br />
**[[3qwi]], [[3qwh]] - ClHSD + hydroxysteroid + NADP<BR />
**[[3qwh]], [[3qwi]] - ClHSD + hydroxysteroid + NADP<BR />
 
*3-α 20-β HSD
*3-α 20-β HSD
**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />
**[[2hsd]] – SeHSD – ''Streptomyces exfoliates''<BR />
**[[1hdc]] – SeHSD + inhibitor
**[[1hdc]] – SeHSD + inhibitor
*Carbonyl reductase/20-β HSD
*Carbonyl reductase/20-β HSD
**[[1n5d]]  - HSD + NADP – pig<br />
**[[1n5d]]  - HSD + NADP – pig<br />
*3-β/17-β HSD
*3-β/17-β HSD
**[[1hxh ]] - CtHSD
**[[1hxh ]] - CtHSD
}}
}}


[[Category:Topic Page]]
[[Category:Topic Page]]
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